Results 211 to 220 of about 1,056,606 (342)

Investigation of cholecystokinin-8s-induced hypophagia in neonatal broiler chicks: Roles of central adrenergic and serotonergic systems. [PDF]

IBRO Neurosci Rep
Zarei H, Mahdavi G, Shahrabi E, Hasani K.   +3 more
europepmc   +1 more source

Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists

, 2011
Linghuan Gao, Min Li, Tao Meng, Hongli Peng, Xin Xie, Yongliang Zhang, Jin Yu, Xin Wang, Libo Zou, Jingkang Shen   +9 more
openalex   +1 more source

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR

, 2021
Hannah C. Feldman, Rajarshi Ghosh, Vincent C. Auyeung, James L. Mueller, Jae‐Hong Kim, Zachary E. Potter, Vidadala V. Narayana, B. Gayani K. Perera, Alina Olivier, Bradley J. Backes, Julie Zikherman, Feroz R. Papa, Dustin J. Maly   +12 more
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TLR9 Inhibition Shortly After Mating Increases Fetal Resorption and Alters B- and T-Cell Costimulatory Phenotypes in an Abortion-Prone Mouse Model. [PDF]

Int J Mol Sci
Lorek D, Kedzierska AE, Slawek A, Kubik P, Chelmonska-Soyta A.   +4 more
europepmc   +1 more source

Correction to “Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor” [PDF]

, 2010

openalex   +1 more source

Metabolic clearance of select opioids and opioid antagonists using hepatic spheroids and recombinant cytochrome P450 enzymes

, 2022
Wing Y. Tuet, Samuel A. Pierce, Matthieu Conroy, Justin N. Vignola, Justin Tressler, Robert C. diTargiani, Bryan J. McCranor, Benjamin Wong   +7 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Antagonism of Kinin Receptors B1 and B2 Attenuates Folic Acid-Induced Tubulointerstitial Fibrosis in Mice. [PDF]

Basic Clin Pharmacol Toxicol
Estrela GR, Budu A, Silva J, Brito R, Wasinski F, Barrera-Chimal J, Araujo RC.   +6 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source