Results 211 to 220 of about 1,005,341 (342)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

The effectiveness of an oral gonadotropin-releasing hormone antagonist relugolix for retained products of conception (RPOC) formed after abortion at less than 22 weeks of gestation: a retrospective study. [PDF]

Front Med (Lausanne)
Sasatsu S, Ono Y, Miyashita D, Yoshihara T, Tanaka K, Owada S, Makino K, Nakagomi A, Ogi M, Ogasawara E, Tagaya H, Fukasawa H, Okuda Y, Yoshino O.   +13 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Fishing for nutrient-competing antagonists for ginseng pathogen control via root biomass. [PDF]

MethodsX
Xiao S, Zhu SH, Cao R.
europepmc   +1 more source

Studies on Nucleic Acid Antagonists. I. Syntheses of 5-Phenylazopyrimidines.

, 1959
Kuniyoshi Tanaka, Einosuke Omura, Toshio Sugawa, Yasushi Sanno, Yukio Ando, Kin-ichi Imai, Minoru Kawashima   +6 more
openalex   +2 more sources

Cholinergic agonist-antagonist interactions on neocortical and limbic EEG activation [PDF]

, 1967
Yamamoto Kjen-Ichi, Edward F. Domino
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death. [PDF]

Cancer Metab
Yang Y, Parfenova E, Vrdoljak N, Minden M, Luc J, Doxey AC, Spagnuolo PA.   +6 more
europepmc   +1 more source

ANTAGONISTIC ACTION OF PYRIDOXINE TO TOXOPYRIMIDINE ON THE GROWTH OF MICE

, 1956
KEN-ICHI TORIGOE, Takeo Kinoshita
openalex   +2 more sources

Steroid Lysis of Protoplasts and Effects of Stabilizers and Steroid Antagonists [PDF]

, 1965
Rodney F. Smith, Donald E. Shay
openalex   +1 more source