Results 211 to 220 of about 471,515 (268)
Some of the next articles are maybe not open access.
New England Journal of Medicine, 2015
info:eu-repo/semantics ...
Vandergheynst, Frederic +2 more
openaire +5 more sources
info:eu-repo/semantics ...
Vandergheynst, Frederic +2 more
openaire +5 more sources
Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire +2 more sources
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire +2 more sources
Progress in Cardiovascular Diseases, 2004
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their use was subsequently expanded to additional disorders, such as angina pectoris, paroxysmal supraventricular tachycardias, hypertrophic cardiomyopathy, Raynaud phenomenon, pulmonary hypertension, diffuse esophageal spasms, and migraine.
Ehud, Grossman, Franz H, Messerli
openaire +2 more sources
Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their use was subsequently expanded to additional disorders, such as angina pectoris, paroxysmal supraventricular tachycardias, hypertrophic cardiomyopathy, Raynaud phenomenon, pulmonary hypertension, diffuse esophageal spasms, and migraine.
Ehud, Grossman, Franz H, Messerli
openaire +2 more sources
Current Topics in Medicinal Chemistry, 2010
Inhibition of CCR2 has been considered as a target for multiple therapeutic diseases including autoimmune disease, atherosclerosis, pain, and metabolic disease, based in part on the critical role this receptor plays on monocyte migration. Numerous companies have reported programs to identify CCR2 antagonists.
Mary, Struthers, Alexander, Pasternak
openaire +2 more sources
Inhibition of CCR2 has been considered as a target for multiple therapeutic diseases including autoimmune disease, atherosclerosis, pain, and metabolic disease, based in part on the critical role this receptor plays on monocyte migration. Numerous companies have reported programs to identify CCR2 antagonists.
Mary, Struthers, Alexander, Pasternak
openaire +2 more sources
Molecular Diversity, 2008
CCR1 (CC Chemokine receptor 1) is a widely studied G protein-coupled receptor target expressed on multiple types of leukocytes. It is implicated in initiating and exacerbating inflammatory conditions and thus is viewed as a good target for autoimmune and inflammatory therapeutic applications. Numerous CCR1 antagonists have been reported.
Jie-Fei, Cheng, Rick, Jack
openaire +2 more sources
CCR1 (CC Chemokine receptor 1) is a widely studied G protein-coupled receptor target expressed on multiple types of leukocytes. It is implicated in initiating and exacerbating inflammatory conditions and thus is viewed as a good target for autoimmune and inflammatory therapeutic applications. Numerous CCR1 antagonists have been reported.
Jie-Fei, Cheng, Rick, Jack
openaire +2 more sources
Cardiology, 2008
At present nitrates remain the initial treatment for relief or prevention of angina in patients with coronary artery disease. In cases where nitrates and beta blockers have been used and are ineffective for managing effort angina, calcium antagonists may be substituted or added to the beta-blocking treatment. When the predominant symptom is rest angina,
C R, Conti +3 more
openaire +2 more sources
At present nitrates remain the initial treatment for relief or prevention of angina in patients with coronary artery disease. In cases where nitrates and beta blockers have been used and are ineffective for managing effort angina, calcium antagonists may be substituted or added to the beta-blocking treatment. When the predominant symptom is rest angina,
C R, Conti +3 more
openaire +2 more sources
1966
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +3 more sources
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
openaire +3 more sources
Letters in Applied Microbiology, 1994
Three groups of substances were identified which inhibit the bactericidal activity of bacitracin. Beside two divalent metals, Mg2+ and Ca2+, and a metabolite with chelating properties, citrate, the most pronounced effect was observed with pyrophosphate. Metals probably prevent access of bacitracin to the lipid carrier whereas metabolites with chelating
Z, Podlesek, A, Comino
openaire +2 more sources
Three groups of substances were identified which inhibit the bactericidal activity of bacitracin. Beside two divalent metals, Mg2+ and Ca2+, and a metabolite with chelating properties, citrate, the most pronounced effect was observed with pyrophosphate. Metals probably prevent access of bacitracin to the lipid carrier whereas metabolites with chelating
Z, Podlesek, A, Comino
openaire +2 more sources
Hormone and Metabolic Research, 1986
The three classes of CCK antagonists illustrate the various factors governing affinity of the antagonists for the CCK receptor. The major influence in determining potency of the cyclic nucleotide derivatives, amino acid derivatives and C-terminal fragments of CCK, are hydrophobic forces.
P N, Maton, R T, Jensen, J D, Gardner
openaire +2 more sources
The three classes of CCK antagonists illustrate the various factors governing affinity of the antagonists for the CCK receptor. The major influence in determining potency of the cyclic nucleotide derivatives, amino acid derivatives and C-terminal fragments of CCK, are hydrophobic forces.
P N, Maton, R T, Jensen, J D, Gardner
openaire +2 more sources