Results 261 to 270 of about 1,541,253 (387)

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

New England Journal of Medicine, 2007
C. Larsen, M. Faulenbach, A. Vaag, A. Vølund, J. Ehses, B. Seifert, T. Mandrup-Poulsen, M. Donath   +7 more
semanticscholar   +2 more sources

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

Molecular Pharmacology, 2014
U. Jin, Syng-Ook Lee, G. Sridharan, Kyongbum Lee, L. Davidson, A. Jayaraman, R. Chapkin, R. Alaniz, S. Safe   +8 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications. [PDF]

BMC Psychiatry
IsHak WW, Hirsch D, Renteria S, Totlani J, Murphy N, Chang T, Abdelsalam R, Salem M, Meyer A, Keerthana S, Liu A, Contreras L, Tadros E, Hedrick R, Danovitch I, Pechnick RN.   +15 more
europepmc   +1 more source

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.

New England Journal of Medicine, 2004
J. Olesen, H. Diener, I. Husstedt, P. Goadsby, D. Hall, Ulrich Meier, S. Pollentier, L. Lesko   +7 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cardiopulmonary bypass-mediated lung ischemia-reperfusion injury: A protective role of sitaxentan. [PDF]

J Int Med Res
Wang Z, Zhan R, Mo L, Zhang Y, Chen Y, Liu L, Bai Y.   +6 more
europepmc   +1 more source

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

EMBO Journal, 2003
D. Winkler, M. Sutherland, James C. Geoghegan, Changpu Yu, T. Hayes, J. Skonier, D. Shpektor, M. Jonas, Brian R. Kovacevich, K. Staehling‐Hampton, M. Appleby, M. Brunkow, J. Latham   +12 more
semanticscholar   +1 more source