Results 261 to 270 of about 1,043,535 (340)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

State-Specific Peptide Design Targeting G Protein-Coupled Receptors. [PDF]

J Chem Inf Model
Xue Y, Wang H, Li J, Hu J, Chen Z, Zheng Z, Liu L, Zhu K, He J, Gong H, Li X, Zhang X, Fang X.   +12 more
europepmc   +1 more source

Endophytic and antagonistic Bacillus amyloliquefaciens 8SE-IF1-derived nanoparticles encumber phytopathogenic oomycetes, fungi, bacteria, and viruses with enhanced growth in tomato seedlings [PDF]

A. Mary Sharmila, Joy Michal Johnson, Sunday Michael Sam, Deepa R. Chandran, B. C. Ajay, G. Heera, S. Sarada, Usha C. Thomas, Swapna Alex, Natarajan Radhakrishanan   +9 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Withdrawal-Induced Delirium in Opioid Dependence: A Systematic Review. [PDF]

Brain Sci
Świderski N, Rodek P, Kucia K.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Correction to: Structural response of mandibular first molars in the presence of proximal contacts: finite element analysis with antagonist teeth and alternative loading applications. [PDF]

Clin Oral Investig
Dorado S, Jimenez-Octavio JR, Riaza P, Peters OA, Arias A.   +4 more
europepmc   +1 more source

H₃-Receptor Antagonists:  Synthesis and Structure−Activity Relationships of Para- and Meta-Substituted 4(5)-Phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles

, 1997
Marco Mor, Fabrizio Bordi, Cláudia Gontijo Silva, Silvia Rivara, Patrizia Crivori, Pier Vincenzo Plazzi, Vigilio Ballabeni, Antonio Caretta, Elisabetta Barocelli, M Impicciatore, Pierre‐Alain Carrupt, Bernard Testa   +11 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source