Results 21 to 30 of about 1,028,152 (221)
Gastroenterology, 2014 BACKGROUND & AIMS There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed.
B. Sands +13 more
semanticscholar +1 more source
New England Journal of Medicine, 2003 BACKGROUND Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both. METHODS We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple myeloma and control subjects to ...
E. Tian +6 more
semanticscholar +1 more source
Critical Care Medicine, 2018 Objective: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials.
N. Meyer +9 more
semanticscholar +1 more source
Towards an efficient inverse static model of a Festo actuator made of two antagonist muscles for hybrid control of its position and stiffness [PDF]
arXiv, 2021 The Festo air muscle is today one of the most known commercial version of the so-called McKibben pneumatic artificial muscle. A major advantage of handmade McKibben muscles, as well as its commercial versions, lies in the possibility it offers of realizing antagonist muscle actuator on the model of the biceps-triceps system.
arxiv
SPA70 is a potent antagonist of human pregnane X receptor
Nature Communications, 2017 Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70
Wenwei Lin +9 more
semanticscholar +1 more source
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Proceedings of the National Academy of Sciences of the United States of America, 1986 The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.
E. Wong +5 more
semanticscholar +1 more source
Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia.
New England Journal of Medicine, 2006 BACKGROUND Hyponatremia (serum sodium concentration,
R. Schrier +6 more
semanticscholar +1 more source
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv
Coordination on Time-Varying Antagonistic Networks [PDF]
arXiv, 2021 This paper studies coordination problem for time-varying networks suffering from antagonistic information, quantified by scaling parameters. By such a manner, interacting property of the participating individuals and antagonistic information can be quantified in a fully decoupled perspective, thus benefiting from merely directed spanning tree ...
arxiv
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source