Results 21 to 30 of about 1,012,981 (340)

Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT2 receptor antagonists

Frontiers in Chemistry, 2022
A novel series of benzenesulfonamide derivatives that selectively act on the AT2 receptor have been designed and synthesized. The binding affinity and functional activity were evaluated by radio-ligand binding analysis and cell neurite outgrowth assay ...
Danhui Wang, Wenjie Zhao, Zuzhi Zhang, Yanchun Zhang, Yanchun Zhang, Jiaming Li, Jiaming Li, Weijun Huang   +7 more
doaj   +1 more source

α_1L-adrenoceptors mediate contraction of human erectile tissue [PDF]

, 2018
α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated
Campbell, Alistair, Chapple, Christopher R., Chess-Williams, Russ, Davis, Beverley J., Naylor, Alisdair L., Sellers, Donna J., Sillar, David   +6 more
core   +1 more source

Antagonistic games [PDF]

Mathématiques et sciences humaines, 2002
Certaines propriétés des jeux à somme nulle sont étendues à différentes classes de jeux à deux joueurs à somme non nulle. Les définitions de ces classes sont basées sur différentes notions d'antagonisme. La notion de jeux presque strictement compétitifs, introduite par Aumann en 1961, est généralisée en gardant l'unicité du paiement d'équilibre de Nash.
openaire   +2 more sources

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
A Dar, A D’Souza, A Foudi, A Nagler, A Peled, AM Greenbaum, AW Roberts, B Nervi, CC Bleul, CL Semerad, D Obrecht, DE Harrison, F Ferraro, F Liu, GA Velders, GL Uy, H Balaguer, H Bonig, H Bonig, H Bonig, H Bonig, H Bonig, HE Broxmeyer, IG Winkler, JP Levesque, JP Levesque, K Balabanian, MA Pulsipher, MA Ryan, MJ Christopher, MM Mueller, MP Rettig, MZ Ratajczak, N Amariglio, P Anderlini, P Anderlini, P Anderlini, S Akizuki, SJ DeMarco, SJ Szilvassy, SM Devine, SP Fricker, T Lapidot, TA Lane, V Saini, WC Liles, Y Katayama, Y Takamatsu   +47 more
core   +1 more source

Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects

Frontiers in Pharmacology, 2011
Receptors for sphingosine-1-phosphate (S1P) have been identified only recently. Their medicinal chemistry is therefore still in its infancy, and few selective agonists or antagonists are available. Furthermore, the selectivity of S1P receptor agonists or
Christian eWaeber, Salvatore eSalomone
doaj   +1 more source

Filling the Gaps in Antagonist CCR5 Binding, a Retrospective and Perspective Analysis

Frontiers in Immunology, 2022
The large number of pathologies that position CCR5 as a central molecular determinant substantiates the studies aimed at understanding receptor-ligand interactions, as well as the development of compounds that efficiently block this receptor.
Yerkezhan Amerzhanova, Luca Vangelista
doaj   +1 more source

Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor

Pharmaceuticals, 2021
Since the first characterization of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in 1992, significant progress has been made in 5-HT2BR research. Herein, we summarize the biological function, structure, and small-molecule pharmaceutical ligands of the 5-
Qing Wang, Yu Zhou, Jianhui Huang, Niu Huang   +3 more
doaj   +1 more source

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Theory of partial agonist activity of steroid hormones

AIMS Molecular Science, 2015
The different amounts of residual partial agonist activity (PAA) of antisteroids under assorted conditions have long been useful in clinical applications but remain largely unexplained.
Carson C. Chow, Karen M. Ong, Benjamin Kagan, S. Stoney Simons, Jr.   +3 more
doaj   +1 more source

Biological Control of Plant Pathogens: A Global Perspective

Microorganisms, 2022
The increase in the world population has generated an important need for both quality and quantity agricultural products, which has led to a significant surge in the use of chemical pesticides to fight crop diseases.
Rachid Lahlali, Said Ezrari, Nabil Radouane, Jihane Kenfaoui, Qassim Esmaeel, Hajar El Hamss, Zineb Belabess, Essaid Ait Barka   +7 more
doaj   +1 more source