Results 321 to 330 of about 1,541,253 (387)

Effect of leukotriene receptor antagonist use on the future risk of Parkinson's disease in older patients with asthma. [PDF]

Brain Commun
Ju C, Chen B, Schrag A, Carroll C, Foltynie T, Wei L.   +5 more
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Toxicities of novel androgen receptor pathway inhibitor targeted therapies in advanced prostate cancer. [PDF]

Curr Opin Urol
Iaxx R, Teyssonneau D, Fallaha C, Grouthier V, Roubaud G.   +4 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

In Silico Assessment of Potential Geroprotectors: From Separate Endpoints to Complex Pharmacotherapeutic Effects. [PDF]

Int J Mol Sci
Stolbov L, Rudik A, Lagunin A, Druzhilovskiy D, Filimonov D, Poroikov V.   +5 more
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Gonadotropin-releasing Hormone Antagonist versus Fixed Progestin-Primed Ovarian Stimulation in <i>In vitro</i> Fertilisation: A Cohort Study. [PDF]

J Hum Reprod Sci
Kothekar MA, Jagtap RA, Katiyar P, Fatemi HM, Lawrenz B.   +4 more
europepmc   +1 more source

Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist. [PDF]

JAAD Case Rep
Mooney N, Grewal A, Pei S, Bogner P, Kuraitis D.   +4 more
europepmc   +1 more source

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c. [PDF]

Cells
Selvaraj R, Lian J, Watts R, Nelson R, Saikali MF, Cummins CL, Lehner R.   +6 more
europepmc   +1 more source