Results 121 to 130 of about 172,666 (300)

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Anterior Cingulate Cortex Causally Supports Meta-Learning.

bioRxiv : the preprint server for biology
In dynamic environments with volatile rewards the anterior cingulate cortex (ACC) is believed to determine whether a visual object is relevant and should be chosen. The ACC may achieve this by integrating reward information over time to estimate which objects are worth to explore and which objects should be avoided.
Treuting, Robert Louis, Boroujeni, Kianoush Banaie, Gerrity, Charles Grimes, Tiesinga, Paul, Womelsdorf, Thilo   +4 more
openaire   +2 more sources

SpartanAnatomy.org: Evaluating a new interactive neuroradiology tool for early medical education

Anatomical Sciences Education, EarlyView.
Abstract Teaching neuroanatomy through the lens of magnetic resonance imaging (MRI) offers medical students a strong foundation for success. However, many existing MRI learning resources lack interactivity and user‐friendliness, require payment, or include an overwhelming number of labeled structures.
Halie Kerver, Cody Lee, Danielle Keller, Ruxin Shi   +3 more
wiley   +1 more source

Evaluating Methods of Correcting for Multiple Comparisons Implemented in SPM12 in Social Neuroscience fMRI Studies: An Example from Moral Psychology [PDF]

, 2018
In fMRI research, the goal of correcting for multiple comparisons is to identify areas of activity that reflect true effects, and thus would be expected to replicate in future studies.
Glenn, Andrea L., Han, Hyemin
core  

Anterior Cingulate Cortex for Consistency Curation

, 2017
Control is essential in all complex systems serving any purpose, and cognitive control is claimed to fill a pivotal role for the cognition of natural agents. The Anterior Cingulate Cortex (ACC) is a neural structure, widely believed to be involved in cognitive control. In the human brain, the ACC undoubtedly takes a center position and features several
openaire   +3 more sources

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Cross-sectional Associations of Fatigue with Cerebral β-Amyloid in Older Adults at Risk of Dementia

Frontiers in Medicine, 2017
Fatigue is a common symptom in the elderly and has also been associated with impaired cognition in older adults. Hence, we sought to explore the cross-sectional relationship between fatigue and cerebral β-amyloid (Aβ) in 269 elderly individuals reporting
Claudie Hooper, Philipe De Souto Barreto, Philipe De Souto Barreto, Nicola Coley, Nicola Coley, Matteo Cesari, Matteo Cesari, Pierre Payoux, Pierre Payoux, Anne Sophie Salabert, Anne Sophie Salabert, Sandrine Andrieu, Sandrine Andrieu, Sandrine Andrieu, Bruno Vellas, Bruno Vellas, for the MAPT/DSA Study Group   +16 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of Cardiac Interoceptive Accuracy in Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Interoceptive impairments have been suggested as an etiological factor in anorexia nervosa (AN) but have not been consistently confirmed across interoceptive dimensions and bodily systems. This systematic review and meta‐analysis provides a focused investigation of cardiac interoceptive accuracy (IAcc) in AN.
Claire Gend, Laure Remy, Annika P. C. Lutz   +2 more
wiley   +1 more source

Temporoparietal Junction Functional Connectivity in Early Schizophrenia and Major Depressive Disorder

Chronic Stress, 2018
Background The temporoparietal junction (TPJ) has been linked to lower-level attentional and higher-level social processing, both of which are affected in schizophrenia (SZ) and major depressive disorder (MDD). We examined resting functional connectivity
Jacob Penner, Elizabeth A. Osuch, Betsy Schaefer, Jean Théberge, Richard W. J. Neufeld, Ravi S. Menon, Nagalingam Rajakumar, Peter C. Williamson   +7 more
doaj   +1 more source