Results 101 to 110 of about 1,151,656 (283)

The Role of Anterior Cingulate Cortex in the Affective Evaluation of Conflict [PDF]

Journal of Cognitive Neuroscience, 2017
AbstractAn influential theory of ACC function argues that this brain region plays a crucial role in the affective evaluation of performance monitoring and control demands. Specifically, control-demanding processes such as response conflict are thought to be registered as aversive signals by ACC, which in turn triggers processing adjustments to support ...
Senne Braem, Joseph A. King, Franziska M. Korb, Ruth M. Krebs, Wim Notebaert, Tobias Egner   +5 more
openaire   +4 more sources

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Anterior Cingulate Cortex, Conflict Monitoring, and Levels of Processing [PDF]

NeuroImage, 2001
It has been hypothesized that the anterior cingulate cortex (ACC) contributes to cognition by detecting conflicts that might occur during information processing, to signal the need to engage top-down attentional processes. The present study was designed to investigate which levels of processing are being monitored by the ACC for the presence of ...
Vincent van Veen, Jonathan D. Cohen 0003, Matthew M. Botvinick, V. Andrew Stenger, Cameron S. Carter   +4 more
openaire   +3 more sources

The neural correlates of desire. [PDF]

PLoS ONE, 2008
In an event-related fMRI study, we scanned eighteen normal human subjects while they viewed three categories of pictures (events, objects and persons) which they classified according to desirability (desirable, indifferent or undesirable).
Hideaki Kawabata, Semir Zeki
doaj   +1 more source

Mapping Brain Activity During Loss of Situation Awareness: an EEG investigation of a basis for top-down influence on perception [PDF]

, 2014
Objective: The objective was to map brain activity during early intervals in loss of Situation Awareness (SA) to examine any co-activity in visual and high-order regions, reflecting grounds for top-down influences on level 1 SA.
Alford, Christopher A, Nikolla, Dritan, White, Sarah, Edgar, Graham, Alford, Chris, Baker, Steven, Catherwood, Diana, Brookes, David, Baker, Stephen, Catherwood, Dianne F, Edgar, Graham K   +10 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Predicting Treatment Response in Depression: The Role of Anterior Cingulate Cortex

International Journal of Neuropsychopharmacology, 2018
Background Identification of biomarkers predicting therapeutic outcome of antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right treatment for a given individual ...
B. Godlewska, M. Browning, R. Norbury, A. Igoumenou, P. Cowen, C. Harmer   +5 more
semanticscholar   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity

Cerebral Cortex, 2018
The human pregenual anterior cingulate cortex (pACC) encompasses 7 distinct cyto- and receptorarchitectonic areas. We lack a detailed understanding of the functions in which they are involved, and stereotaxic maps are not available.
N. Palomero-Gallagher, F. Hoffstaedter, H. Mohlberg, S. Eickhoff, K. Amunts, K. Zilles   +5 more
semanticscholar   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source