Results 51 to 60 of about 147,258 (352)
Resting state electrical brain activity and connectivity in fibromyalgia. [PDF]
PLoS ONE, 2017 The exact mechanism underlying fibromyalgia is unknown, but increased facilitatory modulation and/or dysfunctional descending inhibitory pathway activity are posited as possible mechanisms contributing to sensitization of the central nervous system.
Sven Vanneste +3 more
doaj +1 more source
Journal of Neuroscience, 2018 Pain associates both sensory and emotional aversive components, and often leads to anxiety and depression when it becomes chronic. Here, we characterized, in a mouse model, the long-term development of these sensory and aversive components as well as ...
Jim Sellmeijer +14 more
semanticscholar +1 more source
Optimal decision making and the anterior cingulate cortex
Nature Neuroscience, 2006 Learning the value of options in an uncertain environment is central to optimal decision making. The anterior cingulate cortex (ACC) has been implicated in using reinforcement information to control behavior. Here we demonstrate that the ACC's critical role in reinforcement-guided behavior is neither in detecting nor in correcting errors, but in ...
Steven W. Kennerley +6 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan +46 more
wiley +1 more source
Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response
Nature Communications, 2018 Prefrontal brain areas are implicated in the control of fear behavior. However, how prefrontal circuits control fear response to innate threat is poorly understood.
Jinho Jhang +5 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini +7 more
wiley +1 more source
Post-mortem molecular profiling of three psychiatric disorders
Genome Medicine, 2017 Background Psychiatric disorders are multigenic diseases with complex etiology that contribute significantly to human morbidity and mortality. Although clinically distinct, several disorders share many symptoms, suggesting common underlying molecular ...
Ryne C. Ramaker +19 more
doaj +1 more source
NeuroImage, 2021 Cognitive planning, the ability to develop a sequenced plan to achieve a goal, plays a crucial role in human goal-directed behavior. However, the specific role of frontal structures in planning is unclear.
Marcos Domic-Siede +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin +12 more
wiley +1 more source
Behavioral Shifts and Action Valuation in the Anterior Cingulate Cortex [PDF]
Neuron, 2008 Rapid optimization of behavior requires decisions about when to explore and when to exploit discovered resources. The mechanisms that lead to fast adaptations and their interaction with action valuation are a central issue. We show here that the anterior cingulate cortex (ACC) encodes multiple feedbacks devoted to exploration and its immediate ...
Marie Rothé +4 more
openaire +4 more sources