Results 111 to 120 of about 4,599,290 (296)

Reconstruction of Lateral Skull Base Defects after Combined Parotidectomy and Temporal Bone Resection for Advanced Malignancy

, 2011
Objective: Resection of advanced malignancies of the lateral skull base often results in extensive complex surgical defects, sometimes including dura and temporal bone exposure.
Zoukaa Sargi, Sargi, Zoukaa B, Telischi, Fred F, Robert Gerring, Francisco Civantos, Jacques Morcos, Morcos, Jacques J, Gerring, Robert C, Weed, Donald T, Adrien Eshraghi, David Arnold, Angeli, Simon I, Donald Weed, Arnold, David J, Simon Angeli, Fred Telischi, Civantos, Francisco J, Eshraghi, Adrien   +17 more
core   +1 more source

Use of image guidance in endoscopic endonasal surgeries: a 5-year experience

B-ENT, 2011
Use of image guidance in endoscopic endonasal surgeries: a 5-year experience. Problems/objectives: Endoscopic endonasal surgery (EES) is standard practice in sinonasal disease and is becoming more accepted in the performance of anterior skull base ...
M. Farhadi, M. Jalessi, G. Sharifi, S. Khamesi, E. Bahrami, M. R. Hammami, A. H. Behzadi   +6 more
doaj   +2 more sources

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Anterior Skull Base Pseudomeningoceles: A Scoping Review of Skull Base Pseudomeningoceles

Ear, Nose & Throat Journal
Objectives: The main sites, clinical symptoms, and causal elements linked with pseudomeningoceles at the cranial base are sought by this thorough study. Apart from organizing present data to support therapeutic decision-making, it aims to evaluate diagnostic techniques and the appropriate course of action.
Haifa Alsheikh, Kholoud Alamari, Zahra Alshurafa, Yara Akkielah, Abdullah S. AlDughaither, Naif Alotaibi   +5 more
openaire   +2 more sources

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Human Temporal Bone Removal: Skull Base Block Method

, 2015
Objective: This study aims to describe a novel technique for the efficient harvest of larger temporal bone specimens from human cadavers. Our technique is directly compared with the previously described Modified Block Method (MBM).
Szczupak, Mikhaylo, Eshraghi, Adrien A., Angeli, Simon I., Telischi, Fred F., Dinh, Christine, Moon, Seo   +5 more
core   +1 more source

Dural reconstruction with or without a bone graft of paranasal and anterior skullbase malignancies: Retrospective single-center analysis of 11 cases and review of literature

Brain and Spine
Introduction: The reconstruction of frontobasal defects following oncologic resections of paranasal and anterior skull base (ASB) malignancies remains challenging. Ineffective reconstruction could lead to cerebrospinal fluid leak, meningitis, and tension
Björn Sommer, Ina Konietzko, Maximilian Niklas Bonk, Tina Schaller, Bruno Märkl, Klaus Henning Kahl, Georg Stüben, Johannes Zenk, Ehab Shiban   +8 more
doaj   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source