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Effective Management of Chemotherapy-Induced Cardiotoxicity: A Prospective Follow-Up Study on Alternative Regimens in Bangladeshi Cancer Patients. [PDF]
CureusBhuiyan MZR, Hoque H, Alam S.
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Cardioprotective strategies of ACEi/ARBs and beta-blockers against anthracycline-induced cardiotoxicity in pediatric cancer survivors: a systematic review. [PDF]
CardiooncologySattarpour R, Noori M.
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Expert Opinion on Drug Safety, 2006
The use of anthracyclines is limited by dose-dependent cardiotoxicity. Three forms of anthracycline cardiotoxicity are described; an immediate pericarditis-myocarditis syndrome, an early onset chronic progressive CHF developing during or shortly after therapy and late-onset cardiotoxicity presenting years following treatment.
Charles Swanton, , Robin Jones
exaly +3 more sources
The use of anthracyclines is limited by dose-dependent cardiotoxicity. Three forms of anthracycline cardiotoxicity are described; an immediate pericarditis-myocarditis syndrome, an early onset chronic progressive CHF developing during or shortly after therapy and late-onset cardiotoxicity presenting years following treatment.
Charles Swanton, , Robin Jones
exaly +3 more sources
Acta Oncologica, 1989
The major limitation of the usefulness of anthracyclines is the development of drug resistance. Most of the data related to anthracycline resistance has been obtained in experimental animal tumors or in cultured human cell lines. An important characteristic obtained in these models is the common finding of cross-resistance to a series of drugs ...
Bhushan, Alok +3 more
openaire +4 more sources
The major limitation of the usefulness of anthracyclines is the development of drug resistance. Most of the data related to anthracycline resistance has been obtained in experimental animal tumors or in cultured human cell lines. An important characteristic obtained in these models is the common finding of cross-resistance to a series of drugs ...
Bhushan, Alok +3 more
openaire +4 more sources
International Journal of Oncology, 1996
The genotoxicity and carcinogenicity data from in vitro and in vivo studies conducted during preclinical safety assessment of doxorubicin (DOXO), epirubicin (EPI) and idarubicin (IDA), are reviewed. The genotoxicity assays included a) gene mutation in Salmonella typhimurium with 5 tester strains; b) gene mutation in the V79 mammalian (lung) cell line ...
G, Mazue +10 more
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The genotoxicity and carcinogenicity data from in vitro and in vivo studies conducted during preclinical safety assessment of doxorubicin (DOXO), epirubicin (EPI) and idarubicin (IDA), are reviewed. The genotoxicity assays included a) gene mutation in Salmonella typhimurium with 5 tester strains; b) gene mutation in the V79 mammalian (lung) cell line ...
G, Mazue +10 more
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Morpholinyl anthracyclines: Option for reversal of anthracycline resistance
European Journal of Cancer and Clinical Oncology, 1990Anthracyclines are potent chemotherapeutic drugs, consisting of a 4-ring aglycon and an aminosugar, which both can be substituted. The most widely used are doxorubicin and daunorubicin, the parent drugs. The efficacy, toxicity and drug resistance may be related to different parts of the anthracycline molecule.
de VRIES, Elisabeth GE, Zijlstra, Jan G
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Current Medicinal Chemistry, 1998
This review summarizes the structure, the occurrence and the available data concerning the bioactivity of biosynthetic anthracyclines. The anthracyclines represent an important family of natural products produced by microorganisms of Streptomyces and related genera and include clinically useful agents for the medical treatment of human cancer.
F, Arcamone, G, Cassinelli
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This review summarizes the structure, the occurrence and the available data concerning the bioactivity of biosynthetic anthracyclines. The anthracyclines represent an important family of natural products produced by microorganisms of Streptomyces and related genera and include clinically useful agents for the medical treatment of human cancer.
F, Arcamone, G, Cassinelli
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PHOTOINACTIVATION OF ANTHRACYCLINES*
Photochemistry and Photobiology, 1981Abstract— When adriamycin or daunomycin is irradiated at 366 nm, the drug loses its cytotoxic activity against Sarcoma 180 cells in culture. The half‐time for inactivation is about 9 h. Laboratory fluorescent lights also inactivate these anthracyclines with a half‐time of about one day.
Bruce A. Williams, Thomas R. Tritton
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