Results 1 to 10 of about 27,000 (252)
Cardiotoxicity of Anthracyclines [PDF]
Frontiers in Cardiovascular Medicine, 2020 Cardiotoxicity is a feared side effect that may limit the clinical use of anthracyclines. It may indeed affect the quality of life and survival of patients with cancer, regardless of oncological prognosis. This paper provides an overview of anthracycline-
Daniela Cardinale +2 more
doaj +3 more sources
WikiJournal of Medicine, 2018 Anthracyclines are a clinically important class of antineoplastic agents used to treat a wide variety of solid and blood cancers. The first described anthracycline, daunorubicin, was first isolated from a strain of Streptomyces peucetius in the early ...
Alison Cheong +2 more
doaj +2 more sources
Molecules, 2021 The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of B. adusta CCBAS 930.
Kamila Rybczyńska-Tkaczyk
doaj +1 more source
Cardiac magnetic resonance assessment of right ventricular remodeling after anthracycline therapy
Scientific Reports, 2021 There are limited data on the effects of anthracyclines on right ventricular (RV) structure, function, and tissue characteristics. The goal of this study was to investigate the effects of anthracyclines on the RV using cardiac magnetic resonance (CMR ...
Thiago Ferreira de Souza +13 more
doaj +1 more source
The Role of miRNAs in the Resistance of Anthracyclines in Breast Cancer: A Systematic Review
Frontiers in Oncology, 2022 Breast cancer has been reported as the most common cancer in women globally, with 2.26 million new cases in 2020. While anthracyclines are the first-line drug for breast cancer, they cause a variety of adverse reactions and drug resistance, especially ...
Zihan Si +10 more
doaj +1 more source
DNA damage independent inhibition of NF-κB transcription by anthracyclines
eLife, 2022 Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome.
Angelo Ferreira Chora +25 more
doaj +1 more source
Pharmacogenomics and regulation of apoptosis in acute myeloid leukaemia [PDF]
Medicinski Podmladak, 2020 Acute myeloid leukaemia (AML) is a heterogenous clonal hematopoietic malignancy primarily treated with combination of cytarabine (ara-C) and anthracyclines. Despite high remission rates, especially in younger patients, a vast majority of patients die due
Pravdić Zlatko +1 more
doaj +1 more source
TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?
Membranes, 2023 Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ...
Mayar Soussi +2 more
doaj +1 more source
Experimental Hematology & Oncology, 2012 Background Liposomal formulations of anthracyclines appear to have favorable toxicity profile when compared with conventional anthracyclines in elderly, high risk cardiac patients and patients with prior use of anthracyclines.
Rafiyath Shamudheen M +5 more
doaj +1 more source
Clinics and Practice, 2021 Anthracycline-based regimens with or without anti-human epidermal growth factor receptor (HER) 2 agents such as trastuzumab are effective in breast cancer treatment. Nevertheless, heart failure (HF) has become a significant side effect of these regimens.
Jukapun Yoodee +5 more
doaj +1 more source