Results 21 to 30 of about 27,000 (252)

Exercise Cardio-Oncology: Exercise as a Potential Therapeutic Modality in the Management of Anthracycline-Induced Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2022
Anthracyclines are one of the most effective chemotherapy agents and have revolutionized cancer therapy. However, anthracyclines can induce cardiac injuries through ‘multiple-hits', a series of cardiovascular insults coupled with lifestyle risk factors ...
Dong-Woo Kang, Dong-Woo Kang, Rebekah L. Wilson, Rebekah L. Wilson, Cami N. Christopher, Cami N. Christopher, Amber J. Normann, Amber J. Normann, Oscar Barnes, Jordan D. Lesansee, Gyuhwan Choi, Christina M. Dieli-Conwright, Christina M. Dieli-Conwright   +12 more
doaj   +1 more source

Updates in Anthracycline-Mediated Cardiotoxicity

Frontiers in Pharmacology, 2018
Cardiotoxicity is one of the main adverse effects of chemotheraphy, affecting the completion of cancer therapies and the short- and long-term quality of life.
Canan G. Nebigil, Laurent Désaubry
doaj   +1 more source

Altered Peripheral Blood Gene Expression in Childhood Cancer Survivors With Anthracycline‐Induced Cardiomyopathy – A COG‐ALTE03N1 Report

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Anthracycline‐induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting a need to understand the underlying pathogenesis.
Purnima Singh, Disheet A. Shah, Mariam Jouni, Romina B. Cejas, David K. Crossman, Tarek Magdy, Shaowei Qiu, Xuexia Wang, Liting Zhou, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Ravi Bhatia, Paul W. Burridge, Smita Bhatia   +23 more
doaj   +1 more source

High-sensitivity troponin I as a predictor of left ventricular dysfunction in the use of cardiotoxic anticancer agents for breast cancer in patients with predominantly low and moderate risk of cardiotoxicity

Российский кардиологический журнал, 2022
Aim. To study the significance of monitoring high-sensitivity troponin I (hs-cTnI) for predicting anthracycline-induced left ventricular (LV) dysfunction in the treatment of breast cancer in patients with moderate and low risk of cardiotoxicity (CT ...
V. D. Levina, M. G. Poltavskaya, P. Sh. Chomakhidze, A. A. Meshcheryakov, L. V. Bolotina, T. I. Deshkina, D. S. Valiulina, A. N. Gerasimov, O. V. Andreeva, A. A. Shmeleva, Z.Z.A. Fashafsha, A. R. Levshina, V. P. Sedov   +12 more
doaj   +1 more source

Novel Polyhedral Silsesquioxanes [POSS(OH)₃₂] as Anthracycline Nanocarriers—Potential Anticancer Prodrugs

Molecules, 2020
Anthracyclines belong to the anticancer drugs that are widely used in chemotherapy. However, due to their systemic toxicity they also exert dangerous side effects associated mainly with cardiovascular risks.
Kinga Piorecka, Jan Kurjata, Wlodzimierz A. Stanczyk   +2 more
doaj   +1 more source

Redefining the role of anthracyclines in early breast cancer treatment

Academia Oncology
Anthracyclines have long been a cornerstone of early breast cancer treatment, contributing to significant reductions in recurrence and improvements in survival.
Guilherme Nader-Marta, Martine Piccart
doaj   +1 more source

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan, Sitong Chen, F. Lennie Wong, Nathan Young, Anna Qi, Christopher Davis, Sanjeet Hegde, Nicholas Gloude, Kasey J. Leger, Kelly D. Getz, Francisco Contijoch, Kirsten Ness, Bonnie Ky, Dennis Kuo, Sheri J. Hartman, Saro H. Armenian   +15 more
wiley   +1 more source

Extrato hidroalcoolico da casca do pequi (Caryocar brasiliense) em ratos submetidos à aplicação de doxorrubicina Hydro alcoholic extract of pequi peel (Caryocar brasiliense) in rats submitted to the application of doxorubicin

Ciência Rural, 2013
O objetivo deste estudo foi avaliar o efeito antioxidante do extrato hidroalcoolico da casca do pequi (EHCP) em ratos após a administração de doxorrubicina (DOX).
Léa Resende Moura, Aparecida Conceição Martins, Liliam Aparecida da Rocha Vaz, Stiwens Roberto Trevisan Orpinelli, Thiago Lopes da Silva, Mariana Batista Rodrigues Faleiro, Suzana da Costa Santos, Veridiana Maria Briagnezi Dignani de Moura   +7 more
doaj   +1 more source

Prognostic value of humoral markers in patients with anthracycline-related cardiac dysfunction

Бюллетень сибирской медицины, 2023
Aim. To carry out a 12-month study on the prognostic role of humoral markers responsible for the main mechanisms of initiation of cardiotoxic myocardial damage (endothelin-1, soluble Fas-L, N-terminal pro-brain natriuretic peptide (NT-proBNP), tumor ...
E. V. Grakova, K. V. Kopeva, S. N. Shilov, E. T. Bobyleva, E. N. Berezikova, V. V. Kalyuzhin, A. T. Teplyakov   +6 more
doaj   +1 more source

Pharmacokinetics of Anthracyclines [PDF]

Acta Oncologica, 1989
The plasma pharmacokinetics of the two commonly used anthracyclines doxorubicin and 4'epi-doxorubicin have been studied by reversed phase liquid chromatography with photometric detection. After intravenous administration the plasma pharmacokinetics of doxorubicin and 4'epi-doxorubicin are characterized by the three compartment open model.
openaire   +2 more sources