Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Two-Photon Absorption Properties and Structure-Property Relationships of Natural 9,10-Anthraquinones: A Curated RI-CC2 Dataset. [PDF]
Int J Mol SciSpiegel M.
europepmc +1 more source
Progress in Natural Products Target Discovery Technology
MedComm, Volume 7, Issue 6, June 2026.Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan +7 more
wiley +1 more source
Plant-Environment Interactions, Volume 7, Issue 3, June 2026.ABSTRACT Moringa oleifera is a nutrient‐rich tropical plant containing bioactive secondary metabolites. While these metabolites provide antioxidant and antimicrobial properties, they may reduce digestibility or palatability when used as animal feed.
Teh Exodus Akwa +7 more
wiley +1 more source
Berberine-Mediated BCRP Inhibition Enhances Systemic Exposure of Rhein: A Study to Unravel the Pharmacokinetic Basis of Synergy in Da-Huang-Xiao-Shi Decoction. [PDF]
Pharmaceuticals (Basel)Xu Z +7 more
europepmc +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.Comparative extraction of bioactive polyphenols and antioxidant activities from different plant parts of Rubia cordifolia and Taraxacum officinale using different solvent systems. ABSTRACT This investigation aims to determine the most suitable solvent system and concentration for extracting different polyphenols and the antioxidant activity from ...
Deepti Tiwari +4 more
wiley +1 more source
Rhubarb: Traditional Uses, Phytochemistry, Multiomics-Based Novel Pharmacological and Toxicological Mechanisms. [PDF]
Drug Des Devel TherMiao H, Wang KE, Li P, Zhao YY.
europepmc +1 more source
Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley +1 more source
Dimeric Anthraquinone Rugulosin A Induces Apoptosis in Lung Adenocarcinoma and Targets PI3K/AKT/MAPK Pathways <i>In Silico</i>. [PDF]
ACS OmegaManzano JAH +7 more
europepmc +1 more source