Results 151 to 160 of about 142,050 (194)
Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins* [PDF]
Journal of Biological Chemistry, 2014 Anthrax spores can be aerosolized and dispersed as a bioweapon. Current postexposure treatments are inadequate at later stages of infection, when high levels of anthrax toxins are present. Anthrax toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2).
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Cellular and Molecular Life Sciences (CMLS), 1999
Though its lethal effects were ascribed to an exotoxin almost half a century ago, the pathogenesis of anthrax has yet to be satisfactorily explained. Subsequent work has led to the molecular identification and enzymatic characterization of three proteins that constitute two anthrax toxins.
N S, Duesbery, G F, Vande Woude
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Though its lethal effects were ascribed to an exotoxin almost half a century ago, the pathogenesis of anthrax has yet to be satisfactorily explained. Subsequent work has led to the molecular identification and enzymatic characterization of three proteins that constitute two anthrax toxins.
N S, Duesbery, G F, Vande Woude
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Annual Review of Cell and Developmental Biology, 2003
▪ Abstract Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary combinations to form toxic complexes at the surface of mammalian cells. One of these proteins, protective antigen (PA), transports the other two, edema factor (EF) and lethal factor (LF), to the cytosol.
R John, Collier, John A T, Young
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▪ Abstract Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary combinations to form toxic complexes at the surface of mammalian cells. One of these proteins, protective antigen (PA), transports the other two, edema factor (EF) and lethal factor (LF), to the cytosol.
R John, Collier, John A T, Young
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Critical Reviews in Microbiology, 2001
Anthrax is primarily a disease of herbivores caused by gram-positive, aerobic, spore-forming Bacillus anthracis. Humans are accidental hosts through the food of animal origin and animal products. Anthrax is prevelant in most parts of the globe, and cases of anthrax have been reported from almost every country.
R, Bhatnagar, S, Batra
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Anthrax is primarily a disease of herbivores caused by gram-positive, aerobic, spore-forming Bacillus anthracis. Humans are accidental hosts through the food of animal origin and animal products. Anthrax is prevelant in most parts of the globe, and cases of anthrax have been reported from almost every country.
R, Bhatnagar, S, Batra
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Receptors of anthrax toxin and cell entry [PDF]
Molecular Aspects of Medicine, 2009 Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation.
Françoise Gisou van der Goot +1 more
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In Vivo–produced Anthrax Toxin
Journal of Bacteriology, 1968Specific anthrax antigens were demonstrated in the blood of animals dying from anthrax. These antigens, which appear in the blood at the time when organisms are first detected and whose concentration continues to increase as the number of organisms increases, do not elicit a strong antibody response. The in vivo-produced toxin differs from the in vitro
D C, Fish, R E, Lincoln
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1996
Anthrax is a disease known since antiquity1 and one of the first bacterial infections whose etiology was definitively established. The disease is caused by the Gram-positive, aerobic, spore-forming Bacillus anthracis, first isolated in 1877 by Robert Koch.2 The study of anthrax led to the establishment of Koch’s postulates, a set of criteria for ...
Carlo Petosa, Robert C. Liddington
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Anthrax is a disease known since antiquity1 and one of the first bacterial infections whose etiology was definitively established. The disease is caused by the Gram-positive, aerobic, spore-forming Bacillus anthracis, first isolated in 1877 by Robert Koch.2 The study of anthrax led to the establishment of Koch’s postulates, a set of criteria for ...
Carlo Petosa, Robert C. Liddington
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Stoichiometry of Anthrax Toxin Complexes
Biochemistry, 2001After being proteolytically activated, the protective antigen (PA) moiety of anthrax toxin self-associates to form symmetric, ring-shaped heptamers. Heptameric PA competitively binds the enzymatic moieties of the toxin, edema factor and lethal factor, and translocates them across the endosomal membrane by a pH-dependent process. We used two independent
Jeremy, Mogridge +2 more
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The roles of anthrax toxin in pathogenesis
Current Opinion in Microbiology, 2004Anthrax lethal toxin is a multi-functional virulence factor that has evolved to target multiple host functions to allow for optimal establishment of Bacillus anthracis infection. The toxin appears to play a role in all stages of infection, from germination to the induction of vascular collapse leading to host death.
Mahtab, Moayeri, Stephen H, Leppla
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Anthrax toxin receptor proteins
Biochemical Pharmacology, 2003Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. Here we discuss what is known about the anthrax toxin receptor (ATR), the cellular receptor for anthrax toxin, and how this information is being used to develop treatments for anthrax as well as to understand aspects of cancer. ATR was identified recently as
Kenneth A, Bradley, John A T, Young
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