Results 161 to 170 of about 142,050 (194)
Some of the next articles are maybe not open access.
Structure and Function of Anthrax Toxin
2002Anthrax toxin is a binary A-B toxin comprised of protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). In the presence of a host cell-surface receptor, PA can mediate the delivery of EF and LF from the extracellular milieu into the host cell cytosol to effect toxicity.
D B, Lacy, R J, Collier
openaire +2 more sources
2004
Bacillus anthracis, the etiological agent of anthrax, secretes three polypeptides that assemble into toxic complexes on the cell surfaces of the host it infects. One of these polypeptides, protective antigen (PA), binds to the integrin-like domains of ubiquitously expressed membrane proteins of mammalian cells.
openaire +2 more sources
Bacillus anthracis, the etiological agent of anthrax, secretes three polypeptides that assemble into toxic complexes on the cell surfaces of the host it infects. One of these polypeptides, protective antigen (PA), binds to the integrin-like domains of ubiquitously expressed membrane proteins of mammalian cells.
openaire +2 more sources
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1998
Bacillus anthracis, a Gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subite death in animals, the edema toxin (PA + EF)
F, Brossier, C, Guidi-Rontani, M, Mock
openaire +1 more source
Bacillus anthracis, a Gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subite death in animals, the edema toxin (PA + EF)
F, Brossier, C, Guidi-Rontani, M, Mock
openaire +1 more source
Designing a polyvalent inhibitor of anthrax toxin
Nature Biotechnology, 2001Screening peptide libraries is a proven strategy for identifying inhibitors of protein-ligand interactions. Compounds identified in these screens often bind to their targets with low affinities. When the target protein is present at a high density on the surface of cells or other biological surfaces, it is sometimes possible to increase the biological ...
M, Mourez +7 more
openaire +2 more sources
Three steps to targeting anthrax toxin
Trends in Molecular Medicine, 2002Anthrax toxin is responsible for the severe symptoms and death associated with inhalational anthrax (Fig. 1Fig. 1). Inhaled Bacillus anthracis spores are phagocytosed by macrophages, transported to the lymph nodes where germination occurs up to 60days later, and the new vegetative bacteria produce the toxin.
openaire +2 more sources
Cellular and systemic effects of anthrax lethal toxin and edema toxin
Molecular Aspects of Medicine, 2009Stephen H. Leppla, Mahtab Moayeri
exaly
Chemical Dissection of Protein Translocation through the Anthrax Toxin Pore†
Angewandte Chemie - International Edition, 2011Robert John Collier
exaly