Results 161 to 170 of about 19,232 (195)
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Structure and Function of Anthrax Toxin
2002Anthrax toxin is a binary A-B toxin comprised of protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). In the presence of a host cell-surface receptor, PA can mediate the delivery of EF and LF from the extracellular milieu into the host cell cytosol to effect toxicity.
D B, Lacy, R J, Collier
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Three steps to targeting anthrax toxin
Trends in Molecular Medicine, 2002Anthrax toxin is responsible for the severe symptoms and death associated with inhalational anthrax (Fig. 1Fig. 1). Inhaled Bacillus anthracis spores are phagocytosed by macrophages, transported to the lymph nodes where germination occurs up to 60days later, and the new vegetative bacteria produce the toxin.
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Anthrax toxin: a tripartite lethal combination.
FEBS letters, 2002Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P +5 more
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Anthrax lethal toxin (Bacillus anthracis)
1997Abstract Anthrax lethal toxin (LeTx) induces shock and sudden death in test animals, mimicking the symptoms of systemic anthrax infections (eppla 1991; Hanna et al. 1993). Bacterial strains lacking either of the two LeTx components are highly attenuated, and immunization against the toxin protects animals from 8.
P C Hanna, R J Collier
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Cellular and systemic effects of anthrax lethal toxin and edema toxin
Molecular Aspects of Medicine, 2009Mahtab Moayeri, Stephen H Leppla
exaly
Receptors of anthrax toxin and cell entry
Molecular Aspects of Medicine, 2009F Gisou Van Der Goot
exaly
Chemical Dissection of Protein Translocation through the Anthrax Toxin Pore
Angewandte Chemie - International Edition, 2011R John Collier
exaly