Results 181 to 190 of about 9,869 (220)
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Anthrax Toxin: Primary Site of Action
Journal of Infectious Diseases, 1968Abstract : Administration of anthrax toxin via the cerebrospinal fluid demonstrates positively that the toxin alters the body's physiology, primarily via the central nervous system, and kills by terminal anoxia mediated by the central nervous system.
N S, Remmele +5 more
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Structure and Function of Anthrax Toxin
2002Anthrax toxin is a binary A-B toxin comprised of protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). In the presence of a host cell-surface receptor, PA can mediate the delivery of EF and LF from the extracellular milieu into the host cell cytosol to effect toxicity.
D B, Lacy, R J, Collier
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Three steps to targeting anthrax toxin
Trends in Molecular Medicine, 2002Anthrax toxin is responsible for the severe symptoms and death associated with inhalational anthrax (Fig. 1Fig. 1). Inhaled Bacillus anthracis spores are phagocytosed by macrophages, transported to the lymph nodes where germination occurs up to 60days later, and the new vegetative bacteria produce the toxin.
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Anthrax toxin: a tripartite lethal combination.
FEBS letters, 2002Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P +5 more
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Anthrax lethal toxin (Bacillus anthracis)
1997Abstract Anthrax lethal toxin (LeTx) induces shock and sudden death in test animals, mimicking the symptoms of systemic anthrax infections (eppla 1991; Hanna et al. 1993). Bacterial strains lacking either of the two LeTx components are highly attenuated, and immunization against the toxin protects animals from 8.
P C Hanna, R J Collier
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Biology and evolution of bacterial toxin–antitoxin systems
Nature Reviews Microbiology, 2022Dukas Jurenas +2 more
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Nature Reviews Microbiology, 2021Shannon L Kordus, Dana Borden Lacy
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