Results 91 to 100 of about 24,310,613 (194)

dRVVT Is more Sensitive than KCT or TTI for Detecting Lupus Anticoagulant Activity of Anti-β2-glycoprotein I Autoantibodies

, 1999
SummaryAnti-β2-glycoprotein I (β2-GPI) antibodies behave as classical Lupus Anticoagulants (LA), as they inhibit phospholipid-dependent coagulation reactions and their activity disappears in the presence of excess exogenous phospholipids (PLs).
T. Brocco, A. Biasiolo, V. Pengo, P. Rampazzo   +3 more
core   +1 more source

The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core   +1 more source

A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult‐Onset Primary Lateral Sclerosis‐Like Syndrome

Clinical Genetics, EarlyView.
A 43‐year‐old woman developed a progressive adult‐onset upper motor neuron syndrome fulfilling the clinical criteria for primary lateral sclerosis (PLS), with mild cerebellar involvement. Genetic testing identified a de novo ATP1A3 p.Arg995His variant affecting a highly conserved residue within the transmembrane M8 domain.
Pablo Hernandez‐Vitorique, Marta García de Burgos, Ana Campos Villegas, María José Gómez Heredia, Pilar Carbonell Corvillo   +4 more
wiley   +1 more source

Unmasking Iododerma: A Distinctive Histopathologic Pattern of Neutrophil‐Rich Dermatosis With Haloed Cryptococcoid Bodies in the Setting of Hydralazine Exposure and Autoimmune Serologic Abnormalities

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous iododerma is a rare adverse reaction to iodine‐containing compounds that may clinically and histopathologically mimic infection, vasculitis, malignancy, and other neutrophilic dermatoses. Although most commonly associated with iodinated contrast exposure, a variety of predisposing factors and potential associations have been reported,
Volha Lenskaya, Ana M. Ciurea, Mika Tabata, Teny M. John, Woo Cheal Cho   +4 more
wiley   +1 more source

Clinical characterization of antiphospholipid syndrome by detection of IgG antibodies against β2 -glycoprotein i domain 1 and domain 4/5: ratio of anti-domain 1 to anti-domain 4/5 as a useful new biomarker for antiphospholipid syndrome

, 2015
OBJECTIVE: It has been suggested that only antibodies against domain 1 (D1) of β2 -glycoprotein I (β2 GPI) are pathogenic and diagnostic. The role of antibodies against other β2 GPI domains is still debated.
Norman, Gl, C. Nalli, Meroni, Pl, Claudia Grossi, Flavio Allegri, ANDREOLI, Laura, Cecilia B. Chighizola, Angela Tincani, Laura Andreoli, F. Allegri, Michael Mahler, A. Zanola, Borghi, Mo, Cecilia Nalli, M. Orietta Borghi, F. Pregnolato, L. Andreoli, M. Mahler, C.B. Chighizola, Nalli, C, Alessandra Zanola, Francesca Pregnolato, Pregnolato, F, TINCANI, Angela, Zanola, A, Chighizola, Cb, Allegri, F, Mahler, M, G. L. Norman, Gary L. Norman, M..O. Borghi, Maria Gerosa, P.L. Meroni, Gerosa, M, A. Tincani, C. Grossi, M. Gerosa, Grossi, C, Pier Luigi Meroni   +38 more
core   +1 more source

Antiphospholipid antibody formation during immune checkpoint inhibition in patients with cancer: a prospective cohort study

Research and Practice in Thrombosis and Haemostasis
Background: Immune checkpoint inhibitors (ICIs) significantly improve survival in many cancer types. However, ICIs are associated with an increased risk of venous and arterial thromboembolism, and the underlying mechanisms are incompletely understood. We
Anniek Strijdhorst, Dorien M. Salet, Jente M. Schoenaker, Vossa van der Vegte, Tom T.P. Seijkens, Hanneke W.M. van Laarhoven, Rolf T. Urbanus, Nick van Es   +7 more
doaj   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

The ABCs of antiphospholipid syndrome

The Turkish Journal of Gastroenterology, 2023
Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-
Ayşe Bahar Keleşoğlu Dinçer, Doruk Erkan   +1 more
doaj  

Performance Assessment of Staclot‐LA Assay on Fully Automated Coagulation Analyser for Lupus Anticoagulant Testing Using Internal and External Quality Controls

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction It is recommended to detect lupus anticoagulant (LA) using two phospholipid‐dependent clotting assays, including a LA‐sensitive activated partial‐thromboplastin‐time (aPTT). Among these reagents, Staclot‐LA assay is performed on a mixture of test and normal plasma with and without hexagonal phase phospholipids.
V. Siguret, G. Jourdi, S. Melicine, L. Goubeau, Q. Pomorski, B. Joly‐Laffargue, A. Stepanian, M. Delrue, C. Bon, P. Meijer, E. Curis   +10 more
wiley   +1 more source

The Effects of the oxLDL/β2GPI/anti‐β2GPI Complex on Macrophage Autophagy and its Mechanism

Immunity, Inflammation and Disease
Background Previous research has established that the oxidized low‐density lipoprotein/β2‐glycoprotein I/anti‐β2‐glycoprotein I antibody (oxLDL/β2GPI/anti‐β2GPI) complex can stimulate macrophages to secrete molecules associated with atherosclerosis (AS),
Qianqian Wu, Guiting Zhang, Ting Wang, Hong Zhou   +3 more
doaj   +1 more source