Results 131 to 140 of about 24,310,613 (194)

Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley   +1 more source

Prevalence and Thrombotic Risk Assessment of Anti-β2 Glycoprotein I Domain I Antibodies: A Systematic Review

, 2017
Background To date, the exact prevalence of anti-β2 glycoprotein I domain I (anti-β2GPI-DI) antibodies in patients with antiphospholipid syndrome (APS) and their role when assessing thrombosis risk is uncertain.
Irene Cecchi, Savino Sciascia, Pier Meroni, Massimo Radin, Dario Roccatello   +4 more
core   +1 more source

No Association of Homocysteine, Anticardiolipin Antibody, and Anti-β2 Glycoprotein I Antibody With Portal Venous System Thrombosis in Liver Cirrhosis. [PDF]

Clin Appl Thromb Hemost, 2021
Wang L, Guo X, Xu X, Xu S, Han J, Wang R, Guo Z, Yi F, Qi X.   +8 more
europepmc   +1 more source

Subclinical Cerebral Lesions in Migraine: A Proof‐of‐Concept Study on Platelet Aggregation

European Journal of Neurology, Volume 33, Issue 11, November 2026.
We assessed platelet aggregation in patients with migraine (n = 34) with or without cerebral white‐matter lesions (WMLs) versus matched controls (n = 34), with WMLs volume quantified by MRI (mm3). Aggregation to ADP, collagen, epinephrine, and arachidonic acid was measured; epinephrine‐induced aggregation at 1.25–2.5 μM was overall lower in migraine ...
Ilaria Maestrini, Mariaignazia Curreli, Marta Puma, Costanza Giannì, Eleonora Schiera, Giada Giuliani, Massimiliano Toscano, Marta Altieri, Patrizia Pantano, Fabio Pulcinelli, Vittorio Di Piero   +10 more
wiley   +1 more source

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5616-5630, November 2026.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

Heterogeneous Recognition of beta 2-glycoprotein I by Antibodies from Antiphospholipid Syndrome Patients

, 2000
SummaryBeta 2-glycoprotein I plays a pivotal role in the binding of antiphospholipid antibodies to phospholipid in patients with antiphospholipid syndrome. In this study the nature of the epitopes on beta 2-glycoprotein I (β2-GPI) recognised by sera from
J. Guerin, J. Jackson, R. Sim, B-B. Yu, J. Ferluga, C. Feighery   +5 more
core   +1 more source

CO114 | ANTI-PS/PT IgM IDENTIFIES AN ANTIGEN-DEFINED SUBSET WITHIN LUPUS ANTICOAGULANT POSITIVITY ASSOCIATED WITH THROMBOTIC PHENOTYPE

Bleeding, Thrombosis and Vascular Biology
Background and Aims. Interpretation of isolated lupus anticoagulant (LAC) positivity remains challenging because LAC represents a functional coagulation abnormality rather than an antigen-defined immune response. Anti-phosphatidylserine/prothrombin (aPS/
Raimondo De Cristofaro
doaj  

Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients. [PDF]

Front Med (Lausanne), 2021
Frodlund M, Walhelm T, Dahle C, Sjöwall C.   +3 more
europepmc   +1 more source

β2-Glycoprotein I and Protection from Anti-SSA/Ro60–Associated Cardiac Manifestations of Neonatal Lupus

, 2011
One mechanism to molecularly explain the strong association of maternal anti-Ro60 Abs with cardiac disease in neonatal lupus (NL) is that these Abs initiate injury by binding to apoptotic cardiomyocytes in the fetal heart.
Anthony W. Purcell, Tom P. Gordon, Jill P. Buyon, Joanne H. Reed, Mimi Y. Kim, Robert M. Clancy   +5 more
core   +1 more source

Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial Activation

, 1997
Objective. To investigate the ability of human anti-β2-glycoprotein I (anti-β2GPI) antibodies to recognize the cofactor adherent on endothelial cells (EC) and to modulate endothelial functions. Methods.
L. Guidali, P.L. Meroni, A. Tincani, G. Hughes, C. Buccellati, T. Koike, A. Sala, K. Ichikawa, G. Balestrieri, M. Khamashta, N. Del Papa   +10 more
core   +1 more source