Results 131 to 140 of about 12,264,289 (383)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. [PDF]
, 2019 Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules.
Andersen, Julie +8 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
core +2 more sources
Electroencephalographic changes as neuroscience-based cognitive skill training program
Asian Journal of Medical Sciences, 2020 Background: Brain is an organ that is easily affected by the physical changes.Abnormalities are known to occur with the brain in terms of memory, eyesight, intellect, and balance as the brain is an organ that is easily affected by the physical changes ...
Phakkharawat Sittiprapaporn
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Aging cellular networks: chaperones as major participants
, 2006 We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston +56 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. [PDF]
, 2020 Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear.
Chen, Ye-Guang +13 more
core
A Review of Deep Learning Techniques for Leukemia Cancer Classification Based on Blood Smear Images
Applied BiosciencesThis research reviews deep learning methodologies for detecting leukemia, a critical cancer diagnosis and treatment aspect. Using a systematic mapping study (SMS) and systematic literature review (SLR), thirty articles published between 2019 and 2023 ...
Rakhmonalieva Farangis Oybek Kizi +2 more
doaj +1 more source