Results 31 to 40 of about 2,202,587 (262)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source

Combined krill oil and fish oil attenuates atherosclerosis in apoE− / − mice via ameliorating disordered lipid metabolism and suppressing vascular inflammation

Food, Nutrition and Health
Atherosclerosis, the primary pathological basis of most cardiovascular diseases, remains a leading global cause of mortality, highlighting the need for effective interventions. Krill oil (KO) and fish oil (FO) are key sources of cardiovascular-protective
Lan Yao, Xudong Wu, Jing Huang, Ying Huang, Xi Chen, Xiao Yang   +5 more
doaj   +1 more source

A Deep Learning-Based Approach for Precise Emotion Recognition in Domestic Animals Using EfficientNetB5 Architecture

Eng
The perception of animal emotions is key to enhancing veterinary practice, human–animal interactions, and protecting domesticated species’ welfare. This study presents a unique emotion classification deep learning-based approach for pet animals.
Rashadul Islam Sumon, Haider Ali, Salma Akter, Shah Muhammad Imtiyaj Uddin, Md Ariful Islam Mozumder, Hee-Cheol Kim   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

N6-methyladenosine RNA landscape in the aged mouse hearts

Frontiers in Cardiovascular Medicine
ObjectiveCardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains ...
Xia Jing, Xia Jing, Yingming Li, Zhaofu Liao, Jing-Yu Wu, Zi-Yang Xu, Zhi-Peng Yang, Hai-Liang Mo, Shun Xu, Xinguang Liu, Zhuguo Wu, Jun Tao, Xing-Dong Xiong   +12 more
doaj   +1 more source

Effects of synbiotic supplement on LPS level in Thai smokers: A preliminary study

Asian Journal of Medical Sciences, 2020
Background: The impacts of smoking on the intestinal microbiome piece and arranged assortment have been appeared in different arranged controlled and observational clinical trials in individuals.
Parama Pratummas, Vachrintr Sirisapsombat , Phuttharaksa Phucharoen, Thamthiwat Nararatwanchai, Chaiyavat Chaiyasut, Sasithorn Sirilun , Phakkharawat Sittiprapaporn   +6 more
doaj   +1 more source

The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients

Scientific Reports, 2022
Calciprotein particles (CPPs) are colloids composed of solid-phase calcium-phosphate and serum protein fetuin-A. CPPs form a polydispersed system with different particle size and density.
Hideyuki Mukai, Yutaka Miura, Kazuhiko Kotani, Atsushi Kotoda, Hiroshi Kurosu, Toshiyuki Yamada, Makoto Kuro-o, Yoshitaka Iwazu   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source