Results 31 to 40 of about 2,894,735 (305)

Bupleuri Radix Ameliorates Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Modulation of Tight Junction Protein Expression and Inhibition of Nuclear Factor-κB Activation

Journal of Pharmacopuncture
Objectives: The vascular endothelium plays a central role in the maintenance of vascular homeostasis. Inflammation of vascular endothelial cells has been closely related to the development of a wide range of cardiovascular diseases, including ...
Min Yeong Kim, Eun Jin Bang, Yung Hyun Choi, Su Hyun Hong   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Combined krill oil and fish oil attenuates atherosclerosis in apoE− / − mice via ameliorating disordered lipid metabolism and suppressing vascular inflammation

Food, Nutrition and Health
Atherosclerosis, the primary pathological basis of most cardiovascular diseases, remains a leading global cause of mortality, highlighting the need for effective interventions. Krill oil (KO) and fish oil (FO) are key sources of cardiovascular-protective
Lan Yao, Xudong Wu, Jing Huang, Ying Huang, Xi Chen, Xiao Yang   +5 more
doaj   +1 more source

A Deep Learning-Based Approach for Precise Emotion Recognition in Domestic Animals Using EfficientNetB5 Architecture

Eng
The perception of animal emotions is key to enhancing veterinary practice, human–animal interactions, and protecting domesticated species’ welfare. This study presents a unique emotion classification deep learning-based approach for pet animals.
Rashadul Islam Sumon, Haider Ali, Salma Akter, Shah Muhammad Imtiyaj Uddin, Md Ariful Islam Mozumder, Hee-Cheol Kim   +5 more
doaj   +1 more source

The effect of synbiotics supplement on alcohol use disorders identification test and biochemical parameters, gamma glutamyl transferase, lipopolysaccharide and immunoglobulin a levels, in high risk alcoholics

Asian Journal of Medical Sciences, 2020
Background: Alcohol consumption does not result in dependence or abuse among most people. Nevertheless, a significant group of the population as a whole unavoidably is troubled by chronic alcoholism.Alcohol is involved in a number of diseases, disorders,
Vachrintr Sirisapsombat , Parama Pratummas, Phuttharaksa Phucharoen, Thamthiwat Nararatwanchai , Chaiyavat Chaiyasut, Sasithorn Sirilun , Phakkharawat Sittiprapaporn   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

N6-methyladenosine RNA landscape in the aged mouse hearts

Frontiers in Cardiovascular Medicine
ObjectiveCardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains ...
Xia Jing, Xia Jing, Yingming Li, Zhaofu Liao, Jing-Yu Wu, Zi-Yang Xu, Zhi-Peng Yang, Hai-Liang Mo, Shun Xu, Xinguang Liu, Zhuguo Wu, Jun Tao, Xing-Dong Xiong   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source