Results 1 to 10 of about 6,027 (168)

Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii [PDF]

Heliyon, 2023
A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba.
Alishba, Usman Ahmed, Muhammad Taha, Naveed Ahmed Khan, Uzma Salar, Khalid Mohammed Khan, Ayaz Anwar, Ruqaiyyah Siddiqui   +7 more
doaj   +7 more sources

Anti-amoebic effects of selected herbal extracts against Acanthamoeba species isolated from different borehole water samples from Budiriro District in Harare, Zimbabwe

Infectious Diseases and Herbal Medicine
Acanthamoeba species are the major cause of Acanthamoeba Keratitis (AK) of eyes, Acanthamoeba meningoencephalitis of the central nervous system, and fatal Granulomatous Amoebic Encephalitis (GAE) of the brain in humans.
Kudzai Fambisai, Petros Muchesa, Farisai Chidzwondo, Rumbidzai Mangoyi   +3 more
doaj   +8 more sources

Entamoeba histolytica-induced NETs are highly cytotoxic on hepatic and colonic cells due to serine proteases and myeloperoxidase activities [PDF]

Frontiers in Immunology
During intestinal and liver invasion by the protozoan parasite Entamoeba histolytica, extensive tissue destruction linked to large neutrophil infiltrates is observed.
Fabian Jorge-Rosas, César Díaz-Godínez, Samuel García-Aguirre, Santiago Martínez-Calvillo, Julio César Carrero   +4 more
doaj   +2 more sources

Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica

Pharmaceuticals, 2023
Amoebiasis is produced by the parasite Entamoeba histolytica; this disease affects millions of people throughout the world who may suffer from amoebic colitis or amoebic liver abscess.
Maritza Velásquez-Torres, José Guadalupe Trujillo-Ferrara, Marycarmen Godínez-Victoria, Rosa Adriana Jarillo-Luna, Víctor Tsutsumi, Virginia Sánchez-Monroy, Araceli Posadas-Mondragón, Roberto Issac Cuevas-Hernández, José Angel Santiago-Cruz, Judith Pacheco-Yépez   +9 more
doaj   +1 more source

The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii

Microorganisms, 2022
Acanthamoeba is a free-living protozoan known to cause keratitis most commonly, especially among contact lens wearers. Treatment of Acanthamoeba keratitis is challenging as Acanthamoeba can encyst from the active form, a trophozoite, into a hibernating ...
Hari Kumar Peguda, Nicole A. Carnt, Zi Gu, Naresh Kumar, Mark D. P. Willcox, Rajesh Kuppusamy   +5 more
doaj   +1 more source

Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype

Microorganisms, 2023
Water monitor lizards (WMLs) reside in unhygienic and challenging ecological surroundings and are routinely exposed to various pathogenic microorganisms. It is possible that their gut microbiota produces substances to counter microbial infections.
Noor Akbar, Naveed Ahmed Khan, Alexander D. Giddey, Nelson C. Soares, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

Novel Drug Screening Assay for Acanthamoeba castellanii and the Anti-Amoebic Effect of Carbonic Anhydrase Inhibitors

Journal of Medicinal Chemistry, 2023
Acanthamoeba castellanii is an amoeba that inhabits soil and water in every part of the world. Acanthamoeba infection of the eye causes keratitis and can lead to a loss of vision. Current treatment options are only moderately effective, have multiple harmful side effects, and are tedious.
Susanna Haapanen, Harlan Barker, Fabrizio Carta, Claudiu T. Supuran, Seppo Parkkila   +4 more
openaire   +4 more sources

Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris

Antibiotics, 2022
Naegleria fowleri and Balamuthia mandrillaris are pathogenic free-living amoebae that infect the central nervous system with over 95% mortality rates.
Ruqaiyyah Siddiqui, Mohammad Ridwane Mungroo, Tengku Shahrul Anuar, Ahmad M. Alharbi, Hasan Alfahemi, Adel B. Elmoselhi, Naveed Ahmed Khan   +6 more
doaj   +1 more source

Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone

Antibiotics, 2022
Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf, Noor Akbar, Naveed Ahmed Khan, Muhammad Raza Shah, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

The Effect of Anti-Amoebic Agents and Ce6-PDT onAcanthamoeba castellaniiTrophozoites and Cysts, In Vitro

Translational Vision Science & Technology, 2020
The purpose of this study was to analyze the concentration-dependent effects of biguanides (polyhexamethylene biguanide [PHMB], chlorhexidine [CH]); diamidines (hexamidine-diisethionate [HD], propamidine-isethionate [PD], dibromopropamidine-diisethionate [DD]); natamycin (NM); miltefosine (MF); povidone iodine (PVPI), and chlorin e6 PDT on Acanthamoeba
Shi, Lei, Muthukumar, Vithusan, Stachon, Tanja, Latta, Lorenz, Elhawy, Mohamed Ibrahem, Gunaratnam, Gubesh, Orosz, Erika, Seitz, Berthold, Kiderlen, Albrecht F., Bischoff, Markus, Szentmáry, Nóra   +10 more
openaire   +2 more sources