Results 11 to 20 of about 2,752 (130)

Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone

Antibiotics, 2022
Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf, Noor Akbar, Naveed Ahmed Khan, Muhammad Raza Shah, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

Diseases, 2023
Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system.
Ruqaiyyah Siddiqui, Anania Boghossian, Muhammad Kawish, Tooba Jabri, Muhammad Raza Shah, Tengku Shahrul Anuar, Zainab Al-Shareef, Naveed Ahmed Khan   +7 more
doaj   +1 more source

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]

PLoS ONE, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews, Jon Deakin, May Rajab, Maryam Idris-Usman, Niroshini J Nirmalan   +4 more
doaj   +1 more source

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae

Antibiotics, 2022
Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM).
Ruqaiyyah Siddiqui, Mohammed I. El-Gamal, Anania Boghossian, Balsam Qubais Saeed, Chang-Hyun Oh, Mohammed S. Abdel-Maksoud, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan   +8 more
doaj   +1 more source

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations

Antibiotics, 2023
Pathogenic Acanthamoeba produce keratitis and fatal granulomatous amoebic encephalitis. Treatment remains problematic and often ineffective, suggesting the need for the discovery of novel compounds.
Ruqaiyyah Siddiqui, Mutasem Rawas-Qalaji, Mohammed I. El-Gamal, Sreedevi Sajeev, Jayalakshmi Jagal, Seyed-Omar Zaraei, Rawan M. Sbenati, Hanan S. Anbar, Wolfgang Dohle, Barry V. L. Potter, Naveed Ahmed Khan   +10 more
doaj   +1 more source

Melatonin reduces the severity of experimental amoebiasis

Parasites & Vectors, 2011
Background Melatonin has immunomodulatory effects but very little is known about its influence in protozoan infections, such as Entamoeba histolytica, which causes amoebiasis, a disease with significant morbidity and mortality.
Honório-França Adenilda C, Franca Eduardo L, Oliveira Fabrício MS, França Juliana L, França-Botelho Aline C, Caliari Marcelo V, Gomes Maria A   +6 more
doaj   +1 more source

Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Naegleria fowleri is both a pathogenic and a free-living microbial eukaryote, responsible for the development of primary amoebic meningoencephalitis (PAM) in humans.
Rubén Martín-Escolano, Lyto Yiangou, Eleanna Kazana, Gary K. Robinson, Martin Michaelis, Anastasios D. Tsaousis   +5 more
doaj   +1 more source

The Autofluorescence Patterns of Acanthamoeba castellanii, Pseudomonas aeruginosa and Staphylococcus aureus: Effects of Antibiotics and Tetracaine

Pathogens, 2021
Acanthamoeba Keratitis (AK) can lead to substantial vision loss and morbidity among contact lens wearers. Misdiagnosis or delayed diagnosis is a major factor contributing to poor outcomes of AK.
Hari Kumar Peguda, Saabah B. Mahbub, Tashi Doma Sherpa, Dinesh Subedi, Abbas Habibalahi, Ayad G. Anwer, Zi Gu, Mark D. P. Willcox, Ewa M. Goldys, Nicole A. Carnt   +9 more
doaj   +1 more source

Acanthamoeba and bacteria produce antimicrobials to target their counterpart

Parasites & Vectors, 2014
Background In the microbial ecosystem, microbes compete for space and nutrients. Consequently, some have developed the ability to kill or inhibit the growth of other competing microbes by producing antimicrobial substances.
Junaid Iqbal, Ruqaiyyah Siddiqui, Naveed Ahmed Khan   +2 more
doaj   +1 more source

Effect of povidone iodine, chlorhexidine digluconate and toyocamycin on amphizoic amoebic strains, infectious agents of Acanthamoeba keratitis – a growing threat to human health worldwide

Annals of Agricultural and Environmental Medicine, 2018
Introduction Free-living amoebae, ubiquitous in outer environments, in predisposing circumstances may exist as parasites, infectious agents of Acanthamoeba keratitis.
Marcin Padzik, Wanda Baltaza, David Bruce Conn, Jacek P. Szaflik, Lidia Chomicz   +4 more
doaj   +1 more source