Results 11 to 20 of about 10,570,776 (162)

Anti-amoebic effects of selected herbal extracts against Acanthamoeba species isolated from different borehole water samples from Budiriro District in Harare, Zimbabwe [PDF]

Infectious Diseases and Herbal Medicine
Acanthamoeba species are the major cause of Acanthamoeba Keratitis (AK) of eyes, Acanthamoeba meningoencephalitis of the central nervous system, and fatal Granulomatous Amoebic Encephalitis (GAE) of the brain in humans.
Kudzai Fambisai, Petros Muchesa, Farisai Chidzwondo, Rumbidzai Mangoyi   +3 more
doaj   +7 more sources

Drug modifications: graphene oxide-chitosan loading enhanced anti-amoebic effects of pentamidine and doxycycline [PDF]

Parasitology Research
Acanthamoeba castellanii is the causative pathogen of a severe eye infection, known as Acanthamoeba keratitis and a life-threatening brain infection, named granulomatous amoebic encephalitis. Current treatments are problematic and costly and exhibit limited efficacy against Acanthamoeba parasite, especially the cyst stage. In parallel to drug discovery
Jabri, Tooba, Daalah, Meshal, Alawfi, Bader S., Gul, Jasra, Ahmed, Usman, Shah, Muhammad Raza, Khan, Naveed Ahmed, Siddiqui, Ruqaiyyah, Ying, Tan Yee, Tong, Yeo Jia, Anwar, Ayaz   +10 more
openaire   +4 more sources

Anti-amoebic effects of synthetic acridine-9(10H)-one against brain-eating amoebae

Acta Tropica, 2023
Pathogenic A. castellanii and N. fowleri are opportunistic free-living amoebae. Acanthamoeba spp. are the causative agents of granulomatous amebic encephalitis (GAE) and amebic keratitis (AK), whereas Naegleria fowleri causes a very rare but severe brain infection called primary amebic meningoencephalitis (PAM).
Usman, Ahmed, Mehwish, Manzoor, Sehrish, Qureshi, Muzna, Mazhar, Arj, Fatima, Sana, Aurangzeb, Mehwish, Hamid, Khalid Mohammed, Khan, Naveed Ahmed, Khan, Yasmeen, Rashid, Ayaz, Anwar   +10 more
openaire   +4 more sources

ANTI-MICROBIAL AND ANTI-AMOEBIC ACTIVITY SOME AZOMETHINES - POTENTIAL TEXTILE DYESTUFFS [PDF]

Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2016
In this paper, new synthesized three azomethine derivatives applied in dyeing textiles checking the anti-microbial properties of active components, at the same time [1-3].
DJORDJEVIC Dragan, AMIN Goran, MICIC Aleksandra, MILIC Dragan, SMELCEROVIC Miodrag   +4 more
doaj   +2 more sources

Benzophenone Derivatives as a New Class of Anti-Infectives Against Acanthamoeba spp. [PDF]

Arch Pharm (Weinheim)
Analogues of the human oxidosqualene cyclase inhibitor Ro 48‐8071 were designed, synthesized, and tested against Acanthamoeba hatchetti, one of the pathogens causing Acanthamoeba keratitis. The N‐propargyl derivative 4f showed strong amoebicidal activity with complete eradication of trophozoites and cysts, while exhibiting low toxicity toward human ...
Rimkus T, Geisler H, El-Jourani TB, Moumbock AFA, Schiedel M, Reichl S.   +5 more
europepmc   +2 more sources

Novel Drug Screening Assay for Acanthamoeba castellanii and the Anti-Amoebic Effect of Carbonic Anhydrase Inhibitors

Journal of Medicinal Chemistry, 2023
Acanthamoeba castellanii is an amoeba that inhabits soil and water in every part of the world. Acanthamoeba infection of the eye causes keratitis and can lead to a loss of vision. Current treatment options are only moderately effective, have multiple harmful side effects, and are tedious.
Susanna Haapanen, Harlan Barker, Fabrizio Carta, Claudiu T. Supuran, Seppo Parkkila   +4 more
openaire   +4 more sources

The Effect of Anti-Amoebic Agents and Ce6-PDT onAcanthamoeba castellaniiTrophozoites and Cysts, In Vitro

Translational Vision Science & Technology, 2020
The purpose of this study was to analyze the concentration-dependent effects of biguanides (polyhexamethylene biguanide [PHMB], chlorhexidine [CH]); diamidines (hexamidine-diisethionate [HD], propamidine-isethionate [PD], dibromopropamidine-diisethionate [DD]); natamycin (NM); miltefosine (MF); povidone iodine (PVPI), and chlorin e6 PDT on Acanthamoeba
Shi, Lei, Muthukumar, Vithusan, Stachon, Tanja, Latta, Lorenz, Elhawy, Mohamed Ibrahem, Gunaratnam, Gubesh, Orosz, Erika, Seitz, Berthold, Kiderlen, Albrecht F., Bischoff, Markus, Szentmáry, Nóra   +10 more
openaire   +2 more sources

Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives againstAcanthamoeba castellaniibelonging to the T4 genotype

, 2022
AimsTo determine the anti-amoebic activity of benzofuran/benzothiophene-possessing compounds against Acanthamoeba castellanii of the T4 genotype.Method and resultsA series of benzofuran/benzothiophene-possessing compounds were tested for their anti ...
Saeed, Balsam Qubais, Siddiqui, Ruqaiyyah; id_orcid, Mohammed I El-Gamal, Seyed-Omar Zaraei, Ruqaiyyah Siddiqui, Zaraei, Seyed-Omar, Khan, Naveed Ahmed, Akbar, Noor, El-Gamal, Mohammed I., Noor Akbar, Balsam Qubais Saeed, Naveed Ahmed Khan   +11 more
core   +1 more source

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]

PLoS ONE, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews, Jon Deakin, May Rajab, Maryam Idris-Usman, Niroshini J Nirmalan   +4 more
doaj   +1 more source

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae

Antibiotics, 2022
Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM).
Ruqaiyyah Siddiqui, Mohammed I. El-Gamal, Anania Boghossian, Balsam Qubais Saeed, Chang-Hyun Oh, Mohammed S. Abdel-Maksoud, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan   +8 more
doaj   +1 more source