Results 11 to 20 of about 276,952 (168)

Drug modifications: graphene oxide-chitosan loading enhanced anti-amoebic effects of pentamidine and doxycycline [PDF]

Parasitology Research
Acanthamoeba castellanii is the causative pathogen of a severe eye infection, known as Acanthamoeba keratitis and a life-threatening brain infection, named granulomatous amoebic encephalitis. Current treatments are problematic and costly and exhibit limited efficacy against Acanthamoeba parasite, especially the cyst stage. In parallel to drug discovery
Jabri, Tooba, Daalah, Meshal, Alawfi, Bader S., Gul, Jasra, Ahmed, Usman, Shah, Muhammad Raza, Khan, Naveed Ahmed, Siddiqui, Ruqaiyyah, Ying, Tan Yee, Tong, Yeo Jia, Anwar, Ayaz   +10 more
openaire   +4 more sources

ANTI-MICROBIAL AND ANTI-AMOEBIC ACTIVITY SOME AZOMETHINES - POTENTIAL TEXTILE DYESTUFFS [PDF]

Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2016
In this paper, new synthesized three azomethine derivatives applied in dyeing textiles checking the anti-microbial properties of active components, at the same time [1-3].
DJORDJEVIC Dragan, AMIN Goran, MICIC Aleksandra, MILIC Dragan, SMELCEROVIC Miodrag   +4 more
doaj   +1 more source

Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris

Antibiotics, 2022
Naegleria fowleri and Balamuthia mandrillaris are pathogenic free-living amoebae that infect the central nervous system with over 95% mortality rates.
Ruqaiyyah Siddiqui, Mohammad Ridwane Mungroo, Tengku Shahrul Anuar, Ahmad M. Alharbi, Hasan Alfahemi, Adel B. Elmoselhi, Naveed Ahmed Khan   +6 more
doaj   +1 more source

Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone

Antibiotics, 2022
Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf, Noor Akbar, Naveed Ahmed Khan, Muhammad Raza Shah, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

Diseases, 2023
Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system.
Ruqaiyyah Siddiqui, Anania Boghossian, Muhammad Kawish, Tooba Jabri, Muhammad Raza Shah, Tengku Shahrul Anuar, Zainab Al-Shareef, Naveed Ahmed Khan   +7 more
doaj   +1 more source

Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives againstAcanthamoeba castellaniibelonging to the T4 genotype

, 2022
AimsTo determine the anti-amoebic activity of benzofuran/benzothiophene-possessing compounds against Acanthamoeba castellanii of the T4 genotype.Method and resultsA series of benzofuran/benzothiophene-possessing compounds were tested for their anti ...
Saeed, Balsam Qubais, Siddiqui, Ruqaiyyah; id_orcid, Mohammed I El-Gamal, Seyed-Omar Zaraei, Ruqaiyyah Siddiqui, Zaraei, Seyed-Omar, Khan, Naveed Ahmed, Akbar, Noor, El-Gamal, Mohammed I., Noor Akbar, Balsam Qubais Saeed, Naveed Ahmed Khan   +11 more
core   +1 more source

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae

Antibiotics, 2022
Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM).
Ruqaiyyah Siddiqui, Mohammed I. El-Gamal, Anania Boghossian, Balsam Qubais Saeed, Chang-Hyun Oh, Mohammed S. Abdel-Maksoud, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan   +8 more
doaj   +1 more source

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]

PLoS ONE, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews, Jon Deakin, May Rajab, Maryam Idris-Usman, Niroshini J Nirmalan   +4 more
doaj   +1 more source

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations

Antibiotics, 2023
Pathogenic Acanthamoeba produce keratitis and fatal granulomatous amoebic encephalitis. Treatment remains problematic and often ineffective, suggesting the need for the discovery of novel compounds.
Ruqaiyyah Siddiqui, Mutasem Rawas-Qalaji, Mohammed I. El-Gamal, Sreedevi Sajeev, Jayalakshmi Jagal, Seyed-Omar Zaraei, Rawan M. Sbenati, Hanan S. Anbar, Wolfgang Dohle, Barry V. L. Potter, Naveed Ahmed Khan   +10 more
doaj   +1 more source

Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Naegleria fowleri is both a pathogenic and a free-living microbial eukaryote, responsible for the development of primary amoebic meningoencephalitis (PAM) in humans.
Rubén Martín-Escolano, Lyto Yiangou, Eleanna Kazana, Gary K. Robinson, Martin Michaelis, Anastasios D. Tsaousis   +5 more
doaj   +1 more source