Results 1 to 10 of about 276,952 (168)

Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii [PDF]

Heliyon
A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba.
Alishba, Usman Ahmed, Muhammad Taha, Naveed Ahmed Khan, Uzma Salar, Khalid Mohammed Khan, Ayaz Anwar, Ruqaiyyah Siddiqui   +7 more
doaj   +6 more sources

Anti-amoebic effects of selected herbal extracts against Acanthamoeba species isolated from different borehole water samples from Budiriro District in Harare, Zimbabwe

Infectious Diseases and Herbal Medicine
Acanthamoeba species are the major cause of Acanthamoeba Keratitis (AK) of eyes, Acanthamoeba meningoencephalitis of the central nervous system, and fatal Granulomatous Amoebic Encephalitis (GAE) of the brain in humans.
Kudzai Fambisai, Petros Muchesa, Farisai Chidzwondo, Rumbidzai Mangoyi   +3 more
doaj   +8 more sources

The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii

Microorganisms, 2022
Acanthamoeba is a free-living protozoan known to cause keratitis most commonly, especially among contact lens wearers. Treatment of Acanthamoeba keratitis is challenging as Acanthamoeba can encyst from the active form, a trophozoite, into a hibernating ...
Hari Kumar Peguda, Nicole A. Carnt, Zi Gu, Naresh Kumar, Mark D. P. Willcox, Rajesh Kuppusamy   +5 more
doaj   +4 more sources

Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica

Pharmaceuticals, 2023
Amoebiasis is produced by the parasite Entamoeba histolytica; this disease affects millions of people throughout the world who may suffer from amoebic colitis or amoebic liver abscess.
Maritza Velásquez-Torres, José Guadalupe Trujillo-Ferrara, Marycarmen Godínez-Victoria, Rosa Adriana Jarillo-Luna, Víctor Tsutsumi, Virginia Sánchez-Monroy, Araceli Posadas-Mondragón, Roberto Issac Cuevas-Hernández, José Angel Santiago-Cruz, Judith Pacheco-Yépez   +9 more
doaj   +2 more sources

Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by Acanthamoeba castellanii and Naegleria Fowleri [PDF]

Parasite Epidemiology and Control
Acanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Devandran Apparasamy, Niwasini Krishna Kumar, Chris Izaak Jones, Yee Mon Htet, Haema Thevanayagam, Usman Ahmed, Mohd Farooq Shaik, Ayaz Anwar, Kavitha Rajendran   +8 more
doaj   +2 more sources

Efficacy of phosphonium amphiphilic salts against Acanthamoeba genotype T4 [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Acanthamoebae are opportunistic pathogens causing serious human infections, including granulomatous amoebic encephalitis (GAE) and Acanthamoeba keratitis (AK). The treatment of those infections is limited and difficult to date.
Miloš Lukáč, Martin Pisárčik, Mária Garajová, Julia Walochnik, Daniela Ošustová, Eva Vatrtová, Iryna Bondar, Ferdinand Devínsky, Martin Mrva   +8 more
doaj   +2 more sources

Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype

Microorganisms, 2023
Water monitor lizards (WMLs) reside in unhygienic and challenging ecological surroundings and are routinely exposed to various pathogenic microorganisms. It is possible that their gut microbiota produces substances to counter microbial infections.
Noor Akbar, Naveed Ahmed Khan, Alexander D. Giddey, Nelson C. Soares, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

Novel Drug Screening Assay for Acanthamoeba castellanii and the Anti-Amoebic Effect of Carbonic Anhydrase Inhibitors

Journal of Medicinal Chemistry, 2023
Acanthamoeba castellanii is an amoeba that inhabits soil and water in every part of the world. Acanthamoeba infection of the eye causes keratitis and can lead to a loss of vision. Current treatment options are only moderately effective, have multiple harmful side effects, and are tedious.
Susanna Haapanen, Harlan Barker, Fabrizio Carta, Claudiu T. Supuran, Seppo Parkkila   +4 more
openaire   +4 more sources

PREPARATION AND EVALUATION OF COMPRESSED COATED TABLETS USING POLYELECTROLYTE COMPLEX FOR TARGETED DELIVERY OF ANTI-AMOEBIC DRUG [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2022
An unwanted absorption of anti-amoebic drug at upper gastrointestinal tract (GIT) causes numerous side effects and requires higher doses to get therapeutic effect.
Vaibhav Tiwari, Jawahar Dangi, Sangeeta Tiwari, Leena Kumari, Alok Thakur, Hemant Badwaik   +5 more
doaj   +1 more source

The Effect of Anti-Amoebic Agents and Ce6-PDT onAcanthamoeba castellaniiTrophozoites and Cysts, In Vitro

Translational Vision Science & Technology, 2020
The purpose of this study was to analyze the concentration-dependent effects of biguanides (polyhexamethylene biguanide [PHMB], chlorhexidine [CH]); diamidines (hexamidine-diisethionate [HD], propamidine-isethionate [PD], dibromopropamidine-diisethionate [DD]); natamycin (NM); miltefosine (MF); povidone iodine (PVPI), and chlorin e6 PDT on Acanthamoeba
Shi, Lei, Muthukumar, Vithusan, Stachon, Tanja, Latta, Lorenz, Elhawy, Mohamed Ibrahem, Gunaratnam, Gubesh, Orosz, Erika, Seitz, Berthold, Kiderlen, Albrecht F., Bischoff, Markus, Szentmáry, Nóra   +10 more
openaire   +2 more sources