Results 31 to 40 of about 528,186 (197)

Antineoplastic kinase inhibitors: A new class of potent anti-amoebic compounds

bioRxiv, 2020
Entamoeba histolytica is a protozoan parasite which infects approximately 50 million people worldwide, resulting in an estimated 70,000 deaths every year. Since the 1960s E. histolytica infection has been successfully treated with metronidazole. However,
Conall Sauvey, G. Ehrenkaufer, Da Shi, Anjan Debnath, R. Abagyan   +4 more
semanticscholar   +1 more source

Acanthamoeba induces cell-cycle arrest in host cells [PDF]

, 2004
Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alizadeh, Alsam, Araki-Sasaki, Badenoch, Cao, Chynn, De Jonckheere, Di Gregorio, Dyson, Friedland, Gillett, Gonzalez, Gordon, Harbour, James Sissons, Jones, Khan, Khan, Khan, Khan, Khan, Kwang Sik Kim, Leher, Marciano-Cabral, Martinez, Mathers, Monique Stins, Moore, Morton, Naveed Ahmed Khan, Niederkorn, Pietenpol, Poggioli, Samantha Jayasekera, Selwa Alsam, Shin, Stevaux, van Klink, van Klink, Wright, Yang, Zhan   +41 more
core   +1 more source

Repurposing in vitro approaches for screening anti-parasitic drugs against the brain-eating amoeba Naegleria fowleri

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Naegleria fowleri is both a pathogenic and a free-living microbial eukaryote, responsible for the development of primary amoebic meningoencephalitis (PAM) in humans.
Rubén Martín-Escolano, Lyto Yiangou, Eleanna Kazana, Gary K. Robinson, Martin Michaelis, Anastasios D. Tsaousis   +5 more
doaj   +1 more source

Serum antibodies to Balamuthia mandrillaris, a free-living amoeba recently demonstrated to cause granulomatous amoebic encephalitis [PDF]

, 1999
© 1999 by the Infectious Diseases Society of America. All rights reserved.Free-living amoebae cause three well-defined disease entities: a rapidly fatal primary meningoencephalitis, a chronic granulomatous amoebic encephalitis (GAE), and a chronic ...
Carter, R., Ferrante, A., Huang, Z.
core   +1 more source

The Autofluorescence Patterns of Acanthamoeba castellanii, Pseudomonas aeruginosa and Staphylococcus aureus: Effects of Antibiotics and Tetracaine

Pathogens, 2021
Acanthamoeba Keratitis (AK) can lead to substantial vision loss and morbidity among contact lens wearers. Misdiagnosis or delayed diagnosis is a major factor contributing to poor outcomes of AK.
Hari Kumar Peguda, Saabah B. Mahbub, Tashi Doma Sherpa, Dinesh Subedi, Abbas Habibalahi, Ayad G. Anwer, Zi Gu, Mark D. P. Willcox, Ewa M. Goldys, Nicole A. Carnt   +9 more
doaj   +1 more source

Brain-eating amoebae: Predilection sites in the brain and disease outcome [PDF]

, 2017
Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM).
Khan, Naveed Ahmed *, Ong, Timothy Yu Yee *, Siddiqui, Ruqaiyyah Bano *   +2 more
core   +1 more source

Melatonin reduces the severity of experimental amoebiasis

Parasites & Vectors, 2011
Background Melatonin has immunomodulatory effects but very little is known about its influence in protozoan infections, such as Entamoeba histolytica, which causes amoebiasis, a disease with significant morbidity and mortality.
Honório-França Adenilda C, Franca Eduardo L, Oliveira Fabrício MS, França Juliana L, França-Botelho Aline C, Caliari Marcelo V, Gomes Maria A   +6 more
doaj   +1 more source

Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum. [PDF]

, 2019
We previously showed that Entamoeba histolytica kills human cells through a mechanism that we termed trogocytosis ("trogo-" means "nibble"), due to its resemblance to trogocytosis in other organisms. In microbial eukaryotes like E.
Miller, Hannah W, Ralston, Katherine S, Suleiman, Rene L   +2 more
core   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Recommendations for the management of Acanthamoeba keratitis [PDF]

, 2014
The aim of this letter is to provide the scientific basis of the successful prognosis observed in Acanthamoeba keratitis patients in the absence of anti-Acanthamoeba agents.
Abdul Mannan Baig, Agahan, Hareem Zuberi, Naveed Ahmed Khan, Sweeney   +4 more
core   +1 more source