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Chapter 2. Anti-Anxiety Agents, Anticonvulsants and Sedative-Hypnotics
, 1977 Publisher Summary This chapter describes the metabolic studies of Lorazepam in man and animals, Pinazepams in man, Diazepam in human kidney cortex microsomes and bile, and Nitrazepam in rabbit urine. N-desmethyldiazepam is a new human metabolite of chlorodiazepoxid, e.g Diazepam and its main active metabolite desmethyldiazepam, pass into the breast ...
W HOULIHAN, G BENNETT
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Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agent
Pharmacology Biochemistry and Behavior, 1978 SQ 65,396, a clinically active anti-anxiety agent, enhanced the binding of 3H-diazepam at 1.5 nM. This effect was due to an increase in the affinity for the ligand, without a change in the number of 3H-diazepam binding sites. This action of SQ 65,396 may mediate its anti-anxiety effects by affecting the action of an endogenous modulator of the ...
B, Beer +3 more
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Medicinal chemistry, 2021
BACKGROUND Iminostilbene and 1,2,3-triazole ring containing compounds are considered as beneficial substrates in drug design. OBJECTIVES This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3- triazole pharmacophores (7c-n)
Kariyappa N. Ankali +3 more
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BACKGROUND Iminostilbene and 1,2,3-triazole ring containing compounds are considered as beneficial substrates in drug design. OBJECTIVES This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3- triazole pharmacophores (7c-n)
Kariyappa N. Ankali +3 more
semanticscholar +1 more source
[Anti-emetic and anti-anxiety agents].
Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec, 2010 Jérôme Ouellet
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Avicenna Journal of Phytomedicine, 2017
Objectives: The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L.
B. Razavi, N. Zargarani, H. Hosseinzadeh
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Objectives: The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L.
B. Razavi, N. Zargarani, H. Hosseinzadeh
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Psychedelics as anti-inflammatory agents
International Review of Psychiatry, 2018Serotonin (5-hydroxytryptamine, 5-HT)2A receptor agonists have recently emerged as promising new treatment options for a variety of disorders. The recent success of these agonists, also known as psychedelics, like psilocybin for the treatment of anxiety,
Thomas W. Flanagan, C. Nichols
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Chapter I. Antipsychotic and Anti-anxiety Agents
1968Publisher Summary This chapter elaborates on antipsychotic and antianxiety agents. The reported contribution of pyrrole nuclei to the sedative action of ketone derivatives encouraged the synthesis of relatives of ketone derivatives in which the benzene ring was replaced by pyrrole.
Irwin J. Pachter, Alan A. Rubin
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Chapter 4. Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
1981Publisher Summary Rapid advances have been made in understanding the neurochemical mechanisms of benzodiazepines (BZs) and similar compounds responsible for their therapeutic actions. The “GABA hypothesis” relating to the actions of BZs in the brain continues to gain support.
Richard C. Effland, Manfred F. Försch
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