Results 41 to 50 of about 4,075,451 (292)

Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells.

PLoS ONE, 2023
In an effort to identify novel anti-cancer agents, we employed a well-established High Throughput Screening (HTS) assay to assess the cytotoxic effect of compounds within the ChemBridge DIVERSet Library on a lymphoma cell line.
Risa Mia Swain, Anahi Sanchez, Denisse A Gutierrez, Armando Varela-Ramirez, Renato J Aguilera   +4 more
doaj   +1 more source

Psychological impact of coronavirus disease 2019 pandemic on patients with rheumatological disorders: A web-based cross-sectional multicentric survey

Indian Journal of Rheumatology, 2021
Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in uncertainty and negative psychological outcomes for patients with autoimmune rheumatic diseases for several reasons.
G C Yathish, Yogesh Preet Singh, Shiva Prasad, Nagaraj Srinivasulu, Sharath Kumar, R Subramanian, Pramod Chebbi, Vikramraj Jain, Naman Jain, Satish Kumar   +9 more
doaj   +1 more source

Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder [PDF]

, 2002
Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder.
Buis, C., Mayers, A.G., Baldwin, D.S.
core   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
letizia polito
core   +3 more sources

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders [PDF]

, 2014
Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
Lorenza Rattazzi, Jeffrey W Dalley, Perretti, M, Giuseppa Piras, Perretti, Mauro, D'Acquisto, F, Fulvio D'Acquisto, Rattazzi, Lorenza, Dalley, Jeffrey W., Jeffrey W. Dalley, Panza, E, Gallo, I, Mauro Perretti, Panza, Elisabetta, Piras, G, D'Acquisto, Fulvio, Elisabetta Panza, Gobbetti, T, Rattazzi, L, Gobbetti, Thomas, Dalley, JW, Gallo, Irene, Irene Gallo, Piras, Giuseppa, Thomas Gobbetti   +24 more
core   +2 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Update on Statin Treatment in Patients with Neuropsychiatric Disorders

Life, 2021
Statins are widely accepted as first-choice agents for the prevention of lipid-related cardiovascular diseases. These drugs have both anti-inflammatory and anti-oxidant properties, which may also make them effective as potential treatment marked by ...
Razieh Avan, Adeleh Sahebnasagh, Javad Hashemi, Mahila Monajati, Fatemeh Faramarzi, Neil C. Henney, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar   +8 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Anti-influenza agents from Traditional Chinese Medicine

, 2010
After new human transmissible H1N1 (swine flu) viruses were reported in Mexico and the United States in April 2009, the World Health Organization (WHO) announced the emergence of a novel influenza A virus.
Jiaju Zhou, Zirong Yang, Zhou, Jiaju, Pei-Gen Xiao, Qiong Gu, Wang, Yi-Fei, Wang, YF, Jun Xu, Ge, Hu, Hua Su, Xu, Jun, Gu, Qiong, Yang, Zirong, Hai-Bo Liu, Su, Hua, Liu, Hai-Bo, Xiao, Pei-Gen, Liu, Yanhuai, Hu Ge, Yanhuai Liu, Yi-Fei Wang   +20 more
core   +1 more source