Results 51 to 60 of about 4,267,776 (295)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Anti-Cancer Agents in Medicinal Chemistry

, 2013
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
CAPRANICO, GIOVANNI
core   +1 more source

Update on Statin Treatment in Patients with Neuropsychiatric Disorders

Life, 2021
Statins are widely accepted as first-choice agents for the prevention of lipid-related cardiovascular diseases. These drugs have both anti-inflammatory and anti-oxidant properties, which may also make them effective as potential treatment marked by ...
Razieh Avan, Adeleh Sahebnasagh, Javad Hashemi, Mahila Monajati, Fatemeh Faramarzi, Neil C. Henney, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar   +8 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

The relationship between pain intensity and anxiety, injection speed, and intraocular pressure changes during intravitreal anti-vascular endothelial growth factor injection: the observational pilot study

BMC Ophthalmology
Purpose To evaluate the relationship between the pain severity and the injection speed, anxiety, and intraocular pressure changes during the intravitreal injection (IVI) of anti-vascular endothelial growth factor (anti-VEGF) agents.
Ali Kurt, Emin Utku Altındal
doaj   +1 more source

Effect of Parecoxib and transversus abdominis plane block on postoperative anxiety and cognition: A randomized controlled-trial

Journal of the Pakistan Medical Association
Objective: To investigate the impact of parecoxib and transversus abdominis plane block on postoperative anxiety and early cognitive function in patients undergoing laparoscopic intestinal surgery.
Fuzhen Zhang, Chengzhi Wang, Kan Li, Xingyuan Cheng, Chenxue Meng, Rongtian Kang   +5 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Anti-influenza agents from Traditional Chinese Medicine

, 2010
After new human transmissible H1N1 (swine flu) viruses were reported in Mexico and the United States in April 2009, the World Health Organization (WHO) announced the emergence of a novel influenza A virus.
Jiaju Zhou, Zirong Yang, Zhou, Jiaju, Pei-Gen Xiao, Qiong Gu, Wang, Yi-Fei, Wang, YF, Jun Xu, Ge, Hu, Hua Su, Xu, Jun, Gu, Qiong, Yang, Zirong, Hai-Bo Liu, Su, Hua, Liu, Hai-Bo, Xiao, Pei-Gen, Liu, Yanhuai, Hu Ge, Yanhuai Liu, Yi-Fei Wang   +20 more
core   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Midazolam anti-anxiety compared with placebo

, 2015
Midazolam anti-anxiety compared with ...
Hang Wang (137566), Yuan Gao (159945), Qi Chen (144168), Lufei Wang (718318), Lina Ge (718319)   +4 more
core   +1 more source