Results 31 to 40 of about 4,267,776 (295)

Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole-Based Anticancer Agents as Potent Angiogenesis Inhibitors

open access: yes, 2021
Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines ...
Turan, Gulhan   +16 more
core   +1 more source

Anti-Cancer Agents in Medicinal Chemistry

open access: yes
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Letizia polito
core   +3 more sources

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Prevalence and factors associated with the use of benzodiazepines among teachers in Espírito Santo: a cross-sectional study [PDF]

open access: yesRevista Brasileira de Epidemiologia
Objective: This study analyzed the prevalence and associated factors of benzodiazepine use among teachers in municipalities of Espírito Santo, Brazil, in 2024.
Yohan Cancilheri Mazzini   +6 more
doaj   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE).
Sarah L. Patterson   +7 more
wiley   +1 more source

Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study

open access: yesJournal of Neurodevelopmental Disorders, 2022
Background Rett syndrome (RTT) is a neurodevelopmental disorder most often related to a pathogenic variant in the X-linked MECP2 gene. Internalizing behaviors appear to be common, but standard methods of diagnosing anxiety are not readily applied in this
Caroline B. Buchanan   +20 more
doaj   +1 more source

Models of anxiety for agent deliberation : the benefits of anxiety-sensitive agents blue sky ideas track

open access: yes, 2023
Anxiety is one of the most critical sources of harm to psychological wellbeing, tied to an array of issues, from discomfort and maladaptive coping to severe pathological disorders -making of anxiety one of the largest economic and social healthcare ...
Vanhée, Loïs,, Horned, Arvid,
core  

The association of gout flare resolution with physical activity and sleep: a prospective remote‐monitoring study

open access: yesArthritis Care &Research, Accepted Article.
Objectives This study aimed to determine whether gout flare resolution is associated with physical activity and sleep. These findings were intended to inform the future development of a definition for flare resolution. Methods Data from 81 participants with gout who experienced >1 flare during a 6‐month prospective observational study were included ...
Sarah Stewart   +12 more
wiley   +1 more source

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

open access: yesAntioxidants, 2022
Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber ...
Si-Xia Wu   +7 more
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

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