Results 31 to 40 of about 212,146 (193)

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Gabapentinoid use disorder. Update for clinicians [PDF]

, 2018
Gabapentinoids (gabapentin and pregabalin) are versatile drugs, indicated mainly for epilepsy and neuropathic pain, and have long been viewed as agents with little potential for abuse.
Ann LeQuang, Jo, Bisney, John, Coluzzi, Flaminia, Gharibo, Christopher, Taylor, Robert, V Pergolizzi, Joseph   +5 more
core  

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment [PDF]

, 2012
Treatment for CIN is usually undertaken in an outpatient colposcopy clinic to remove the pre-cancerous cells from the cervix. It commonly involves lifting the cells off the cervix with electrically heated wire (diathermy) or laser, or destroying the ...
AI-Kurdi, Anthony, Connell, Crompton, Cruickshank, Deeks, DerSimonian, Diakomanolis, Duncan, Frega, Higgins, Howells, Huskisson, Johnson, Johnston, Jordan, Lee, Lipscomb, Lowles, Martin-Hirsch, Melzack, Mikhail, Moore, Peto, Rogstad, Sammarco, Sant, Sarkar, Sharp, Spielberger, Winters, Zigmond   +31 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Benzodiazepine anti-anxiety agents: prevalence and correlates of use in a southern community. [PDF]

American Journal of Public Health, 1991
BACKGROUND: Benzodiazepine anti-anxiety agents are the most widely prescribed psychotherapeutic drugs in the United States today. Recent evidence, however, suggests that their use may be decreasing. METHODS: We examine the population prevalence and correlates of use of benzodiazepine anxiolytics at the Duke site of the NIMH-sponsored Epidemiologic ...
M, Swartz, R, Landerman, L K, George, M L, Melville, D, Blazer, K, Smith   +5 more
openaire   +2 more sources

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial. [PDF]

, 2019
BackgroundWe describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).ObjectiveTo describe the feasibility and effectiveness of an acupressure ...
Adcock, Robyn, Banerjee, Anu, Dvorak, Christopher C, Golden, Carla, Hartogensis, Wendy, Hecht, Frederick M, Hu, Hiroe, Lown, E Anne, Mangurian, Christina, Melton, Alexis, Morgan, Michael, Shear, Deborah, Vittinghoff, Eric   +12 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

PTSD in the 20th Century American Military: Its Diagnosis, Effects, Treatment, and Management, With a Focus on the Vietnam War [PDF]

, 2016
Soldiers have been affected by PTSD for as long as war has existed. The American Military in the twentieth century is no exception. PTSD did not become a diagnosable disease until 1980, and before then it was misdiagnosed as different anxiety disorders ...
Connell, Christy L
core   +1 more source

Microbiota and chronic inflammatory arthritis. an interwoven link [PDF]

, 2016
Background: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease.
D'Amelio, Raffaele, Laganà, Bruno, Manuela Rosado, M, Picchianti Diamanti, Andrea   +3 more
core   +2 more sources