Results 31 to 40 of about 383,105 (350)

Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

Frontiers in Physiology, 2021
BackgroundCombined treatment with anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2) antibody, in patients with HER2-positive cancer is limited by cardiotoxicity, as ...
Claudia Altomare, Alessandra Maria Lodrini, Alessandra Maria Lodrini, Giuseppina Milano, Giuseppina Milano, Vanessa Biemmi, Edoardo Lazzarini, Sara Bolis, Sara Bolis, Nicolò Pernigoni, Eleonora Torre, Martina Arici, Mara Ferrandi, Lucio Barile, Lucio Barile, Lucio Barile, Marcella Rocchetti, Giuseppe Vassalli, Giuseppe Vassalli, Giuseppe Vassalli   +19 more
doaj   +1 more source

Molecular Insights in Atrial Fibrillation Pathogenesis and Therapeutics: A Narrative Review

Diagnostics, 2021
The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years, affecting the quality of life of millions of people, increasing mortality and morbidity, and beleaguering health care systems.
Konstantinos A. Papathanasiou, Sotiria G. Giotaki, Dimitrios A. Vrachatis, Gerasimos Siasos, Vaia Lambadiari, Konstantinos E. Iliodromitis, Charalampos Kossyvakis, Andreas Kaoukis, Konstantinos Raisakis, Gerasimos Deftereos, Theodore G. Papaioannou, Georgios Giannopoulos, Dimitrios Avramides, Spyridon G. Deftereos   +13 more
doaj   +1 more source

The Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channel Blocker Ivabradine Does Not Prevent Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia

Frontiers in Pharmacology, 2020
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na+ channel inhibitors, sympathetic denervation, or by implanting a defibrillator ...
Hanna Bueno-Levy, David Weisbrod, Dor Yadin, Shiraz Haron-Khun, Shiraz Haron-Khun, Asher Peretz, Edith Hochhauser, Michael Arad, Bernard Attali   +8 more
doaj   +1 more source

Improving of Robotic Virtual Agent's errors that are accepted by reaction and human's preference [PDF]

arXiv, 2023
One way to improve the relationship between humans and anthropomorphic agents is to have humans empathize with the agents. In this study, we focused on a task between an agent and a human in which the agent makes a mistake. To investigate significant factors for designing a robotic agent that can promote humans empathy, we experimentally examined the ...
arxiv  

Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]

, 2003
<b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT₄ receptors.
Andrew C Rankin, Antony J Workman, BERS, BLONDEL, Davide Pau, DAWODU, GRAMMER, GRIMM, HALL, HEGDE, JAHNEL, JAHNEL, JIA, JOSEPH, KAMATH, Kathleen A Kane, KAUMANN, KAUMANN, KAUMANN, LEVY, MEDHURST, MOE, NATTEL, NEHER, OUADID, RAHME, SANDERS, TONINI, WANG, WANGEMANN, WORKMAN, WORKMAN, YUE   +32 more
core   +2 more sources

Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms

Molecules, 2023
Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD).
Silu Liu, Weijia Chen, Yan Zhao, Ying Zong, Jianming Li, Zhongmei He   +5 more
doaj   +1 more source

Cooperative and Competitive Biases for Multi-Agent Reinforcement Learning [PDF]

arXiv, 2021
Training a multi-agent reinforcement learning (MARL) algorithm is more challenging than training a single-agent reinforcement learning algorithm, because the result of a multi-agent task strongly depends on the complex interactions among agents and their interactions with a stochastic and dynamic environment.
arxiv  

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database [PDF]

, 2013
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US ...
A Bate, A Clarke, A Pariente, AK Chung, Ariola Koci, B Darpo, BJ Drew, C Meyer-Massetti, DM Roden, DW Hough, E Poluzzi, E Poluzzi, E Poluzzi, E Raschi, E Raschi, Edoardo Spina, Elijah R. Behr, Elisabetta Poluzzi, Emanuel Raschi, EP Puijenbroek van, ER Behr, F Ponti De, F Ponti De, F Rani, Fabrizio De Ponti, GC Alexander, GK Isbister, H Verdoux, J Nielsen, J Papay, K Jolly, K Titier, LC Wittkampf, LS Schneider, Miriam Sturkenboom, NP Tatonetti, P Kannankeril, P Manu, P Vigneault, RC Owens Jr, RR Shah, S Dhillon, S Hennessy, S Kongsamut, S Leucht, SM Straus, Ugo Moretti, W Crumb, W Crumb, WA Ray, WA Ray, WJ Crumb Jr, WP Stephenson, Y Suzuki   +53 more
core   +3 more sources

Fact-based Agent modeling for Multi-Agent Reinforcement Learning [PDF]

arXiv, 2023
In multi-agent systems, agents need to interact and collaborate with other agents in environments. Agent modeling is crucial to facilitate agent interactions and make adaptive cooperation strategies. However, it is challenging for agents to model the beliefs, behaviors, and intentions of other agents in non-stationary environment where all agent ...
arxiv  

Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]

, 2003
<b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A., Norrie, J., Rankin, A.C., Russell, J.A., Workman, A.J.   +4 more
core   +1 more source