Results 61 to 70 of about 383,105 (350)

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Agents Play Mix-game [PDF]

, 2005
In mix-game which is an extension of minority game, there are two groups of agents; group1 plays the majority game, but the group2 plays the minority game. This paper studies the change of the average winnings of agents and volatilities vs. the change of mixture of agents in mix-game model. It finds that the correlations between the average winnings of
arxiv   +1 more source

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]

, 2015
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C., Choisy, Stéphanie C., Hancox, Jules C., James, Andrew F., Jones, Sandra A., Kim, Shang-Jin   +5 more
core   +1 more source

Antiaritmički efekti novosintetisanih derivata propafenona [PDF]

, 2022
It is well known that the presence of different chemical groups in drug molecules influences their pharmacological properties. The aim of our study is to investigate whether newly synthesized derivatives of propafenone, with changes in benzyl moiety ...
Crevar, Milkica, Džudović, Boris, Gojković-Bukarica, Ljiljana, Ivković, Branka, Opačić, Dragan   +4 more
core   +1 more source

Anti‐Motion Artifacts Iontronic Sensor for Long‐Term Accurate Fingertip Pulse Monitoring

Advanced Science, EarlyView.
Flexible pressure sensors are essential for pulse monitoring and cardiovascular disease diagnosis but are affected by motion artifacts (MAs) due to stretching stress. The S‐smooth sensor with a soft‐hard stretchable interface that dissipates energy, reducing MAs by 90% is developed.
Jia You, Mingyang Lu, Lamu Dazhen, Mengjie Gao, Ruiyan Zhang, Wendong Li, Fan Lei, Wei Ren, Guangxian Li, Junlong Yang   +9 more
wiley   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

When Do Introspection Axioms Matter for Multi-Agent Epistemic Reasoning? [PDF]

EPTCS 297, 2019, pp. 121-139, 2019
The early literature on epistemic logic in philosophy focused on reasoning about the knowledge or belief of a single agent, especially on controversies about "introspection axioms" such as the 4 and 5 axioms. By contrast, the later literature on epistemic logic in computer science and game theory has focused on multi-agent epistemic reasoning, with the
arxiv   +1 more source

Role of pharmacotherapy in Brugada syndrome [PDF]

, 2004
In patients who undergo aborted sudden cardiac death or syncope of unknown origin (symptomatic Brugada syndrome), no one argues that the implantation of an ICD is the first-line therapy regardless of the findings of the EP study.
Tsuchiya, Takeshi
core   +1 more source