Results 191 to 200 of about 3,604,842 (297)

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Ferroptosis as an Emerging Therapeutic Target in Allergic Diseases. [PDF]

Drug Des Devel Ther
Wang Z, Zheng W, Wang H, An C, Wang Y, Zhang J.   +5 more
europepmc   +1 more source

Targeting of MAPK-ERK1/2 signaling by metformin in asthma: an updated mechanistic insight. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Hassan ME, Al-Kuraishy HM, Alexiou A, Papadakis M, Faheem SA, Rashwan EK, Batiha GE.   +6 more
europepmc   +1 more source

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

An Extended Transcriptomic Landscape of Human Skin Mast Cells: Unveiling Lineage‐Specific Noncoding RNA Dynamics in FcεRI Activation

Allergy, EarlyView.
FcεRI cross‐linking triggers widespread transcriptional reprogramming in human skin mast cells (> 5000 genes, > 6400 promoters, and 48 novel mast cell‐enriched lncRNAs). Breast skin and foreskin mast cells share core transcriptional programs but differ selectively in tryptase isoenzymes and IL‐8/IL‐1RA release.
Gürkan Bal, Kristin Franke, Stefan Frischbutter, Shiva Raj Tripathi, Kayoko Yasuzawa, Jordan A. Ramilowski, Michihira Tagami, Takeya Kasukawa, Michiel de Hoon, Jay W. Shin, Piero Carninci, Torsten Zuberbier, Magda Babina   +12 more
wiley   +1 more source

Biologic Use in Type 2 versus Non-Type 2 Asthma: Similarities, Differences, and Challenges. [PDF]

J Inflamm Res
Maglio A, D'Auria LO, Franzese A, Liguori ME, Gramazio S, Arnone G, Longobardi V, Pelaia C, Pelaia G, Calabrese C, Vitale C, Vatrella A.   +11 more
europepmc   +1 more source

Expanding the Utility of Gold Nanocluster “Allergolds” to Peanut Allergen Ara h 2

Allergy, EarlyView.
Gage O. Leighton, Victor Martinez‐Macias, Emmanuel R. De Diavoukana, Adalia Wambolt, Xunyang Chen, Scott A. Gabel, Scott A. Smith, Sarita U. Patil, Geniece Hallett‐Tapley, Alexander C. Y. Foo, Geoffrey A. Mueller   +10 more
wiley   +1 more source

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

Lung-Targeted Delivery of Nebulized α‑Asaronol Attenuates Airway Inflammation and Hyperresponsiveness in Murine Asthma Models. [PDF]

ACS Pharmacol Transl Sci
Bai Y, Zhao X, Wang F, Liu D, Diao Y, Sun Y, Zhao Y, Zhang L, Bai Y, Wang S, Jia P, Zhao Y, Zheng X.   +12 more
europepmc   +1 more source

Eosinophilic Oesophagitis and Incidence of Gastrointestinal Cancer: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
Among 9115 patients with eosinophilic oesophagitis in Denmark, excess gastrointestinal cancer in the first year after diagnosis most likely reflected diagnostic work‐up. Beyond 1 year, oesophageal adenocarcinoma and hepatocellular carcinoma remained more frequent than expected; most patients with oesophageal cancer had prior Barrett's oesophagus ...
Gencer Kurt, Dóra Körmendiné Farkas, Evan S. Dellon, Elizabeth T. Jensen, Henrik Toft Sørensen   +4 more
wiley   +1 more source