Results 51 to 60 of about 106,846 (305)

Parents’ Beliefs about Medicines and Their Influence on Inhaled Corticosteroid Adherence in Children with Asthma

Children
The most widespread chronic condition observed amid children globally is asthma. Only half of children with asthma adhere to their prescribed inhaled corticosteroids (ICS) therapy.
Jasna Petrić Duvnjak, Anita Ursic, Antonela Matana, Ivana Medvedec Mikic   +3 more
doaj   +1 more source

Local anaesthetic medication for the treatment of asthma

Memorias do Instituto Oswaldo Cruz, 2005
It is presumed that drugs able to prevent bronchial spasm and/or inflammation may have therapeutic potential to control asthma symptoms. The local anaesthetic lidocaine has recently received increased attention as an alternative form of treatment for ...
Rodrigo A Siqueira, Jorge CS Costa, Renato SB Cordeiro, Magda F Serra, Patrícia MR e Silva, Marco A Martins   +5 more
doaj   +1 more source

SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-1HTHIAZOLO[3,2-f]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTIINFLAMMATORY AGENTS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2015
In this study, the design, synthesis and preliminary pharmacological investigation of novel 1,3-diethyl-8-disubstituted xantines 12-18, 1,3,6-trisubstituted-1H-thiazolo[3,2-f]purine-2,4diones 19-25 and xanthine Schiff bases 28-33 was described.
Ahmad Talhouni, Reham Shmeis, Alaa Hayallah   +2 more
doaj   +1 more source

Glucuronides in anti-cancer therapy [PDF]

, 2003
Glucuronide prodrugs have shown promising efficacy in anti-cancer therapy due to their increased specificity and reduced systemic toxicity. The prodrugs can be used in prodrug monotherapy (PMT), which is based on elevated tumor beta-glucuronidase ...
Wu, Bingyuan, Chen, Xi, Wang, Peng George   +2 more
core   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review

Asian Pacific Journal of Tropical Biomedicine, 2017
The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids (BA). The oleo gum resin obtained from Indian variety i.e.
Farah Iram, Shah Alam Khan, Asif Husain
doaj   +1 more source

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases

Molecules, 2022
The inflammatory response is a central aspect of the human immune system that acts as a defense mechanism to protect the body against infections and injuries.
Juman Mohammed Rasmi Alamil, Keshav Raj Paudel, Yinghan Chan, Dikaia Xenaki, Jithendra Panneerselvam, Sachin Kumar Singh, Monica Gulati, Niraj Kumar Jha, Deepak Kumar, Parteek Prasher, Gaurav Gupta, Raniya Malik, Brian George Oliver, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan   +15 more
doaj   +1 more source

New Anti-Telomerase Anti-Cancer Agents [PDF]

, 2008
The unlimited proliferative potential of cancer cells depends on telomere maintenance. Optimal telomerase activity requires in chromosomal DNA an unfolded single-stranded telomeric overhang.
PETRACCONE, LUIGI
core