Results 51 to 60 of about 16,424 (267)

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Asthma and Therapeutics: Recombinant Therapies in Asthma

Allergy, Asthma & Clinical Immunology, 2005
Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents.
Cockcroft Donald W
doaj   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Design, Development and Evaluation of Extended Release Tablets of Anti-asthmatic Agents using various Polymers

International Journal of Research and Development in Pharmacy & Life Sciences, 2018
The aim of this investigation was to define and assess Salbutamol sulphate and Theophylline framework tablets, prolonged discharge dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Powder blends of the drugs (Salbutamol sulphate and Theophylline) and polymers (HPMC K100M and Xanthan Gum) were evaluated for loose bulk ...
Anil Kumar, Naveen Goyal
openaire   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, on behalf of the French Vasculitis Study Group and the Eosinophilic Granulomatosis with Polyangiitis European Study Group   +35 more
wiley   +1 more source

A current review on animal models of anti-asthmatic drugs screening

Frontiers in Pharmacology
Asthma is a chronic inflammatory respiratory condition characterised by airway constriction, smooth muscle spasm, and severe morbidity. It affects around 300 million people globally, with children being especially vulnerable. Despite its worldwide effect,
Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma   +5 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ANTI-ASTHMATIC AGENT USING VARIOUS POLYMERS

Journal of Drug Delivery and Therapeutics, 2013
The objective of the present study was to develop matrix tablets of salbutmol sulphate sustained release dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Compatibility study was performed through Fourier Transformer Infrared spectroscopy revealed that there no interaction between drug and polymers.
Prakash B Mote, Pavan K. Rawat K Rawat, Shailendra K Singh, Nityanand S Zadbuke, Amarjit A Salunke, Vivek B Rajendra   +5 more
openaire   +2 more sources

The integration of the British Pharmacological Society's prescription safety assessment into the WHO 6‐step model of rational pharmacotherapy in a Turkish medical school

British Journal of Clinical Pharmacology, EarlyView.
Aims At Koç University School of Medicine, a one‐week rational pharmacotherapy (RPHM) programme, modelled after WHO 6‐step, has been introduced in the fourth‐year curriculum to improve prescription skills. For efficient problem‐based learning (PBL) sessions on a prespecified topic, students need to brush up on basic pharmacology knowledge, so we ...
Sinem Ezgi Gülmez, Gülnihal Özcan, Hakan S. Orer   +2 more
wiley   +1 more source

Anti-inflammatory and antioxidant effects of Allolobophora caliginosa extract against Ovalbumin-induced airway inflammation in asthmatic female BALB/c mice

Beni-Suef University Journal of Basic and Applied Sciences
Background The chronic inflammatory and immunological disease "Asthma" is characterized by oxidative stress disruptions and is typically treated with glucocorticoids, the most potent anti-inflammatory agents.
Islam Ahmed Abdelmawgood, Tarek Atia, Abeer Mahmoud Badr, Ayman Saber Mohamed, Mennatallah H. Abdelaziz, Noha Ahmed Mahana, Hader Ibrahim Sakr, Reham S. Al-Fakharany, Tamer D. Abdelaziz, Ahmed A. Damanhory, Adel Alghamdi, Marwa Ahmed Abdelfattah, Hadeer Hesham Abdelfattah   +12 more
doaj   +1 more source