Results 31 to 40 of about 106,771 (304)

Mycophenolate Mofetil, an Inhibitor of Inosine Monophosphate Dehydrogenase, and Tofacitinib, a Janus Kinase Inhibitor, Attenuate Airway Inflammation and Hyperresponsiveness in a Mouse Model of Allergic Asthma

Molecules
Treatment-resistant asthma remains an unresolved clinical problem and a challenge for current medical science. Consequently, there is a growing and urgent need to develop novel or alternative therapeutic options for the treatment of asthma.
Bernard Kravčenia, Tomasz Maślanka
doaj   +1 more source

SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-1HTHIAZOLO[3,2-f]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTIINFLAMMATORY AGENTS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2015
In this study, the design, synthesis and preliminary pharmacological investigation of novel 1,3-diethyl-8-disubstituted xantines 12-18, 1,3,6-trisubstituted-1H-thiazolo[3,2-f]purine-2,4diones 19-25 and xanthine Schiff bases 28-33 was described.
Ahmad Talhouni, Reham Shmeis, Alaa Hayallah   +2 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Parents’ Beliefs about Medicines and Their Influence on Inhaled Corticosteroid Adherence in Children with Asthma

Children
The most widespread chronic condition observed amid children globally is asthma. Only half of children with asthma adhere to their prescribed inhaled corticosteroids (ICS) therapy.
Jasna Petrić Duvnjak, Anita Ursic, Antonela Matana, Ivana Medvedec Mikic   +3 more
doaj   +1 more source

Local anaesthetic medication for the treatment of asthma

Memorias do Instituto Oswaldo Cruz, 2005
It is presumed that drugs able to prevent bronchial spasm and/or inflammation may have therapeutic potential to control asthma symptoms. The local anaesthetic lidocaine has recently received increased attention as an alternative form of treatment for ...
Rodrigo A Siqueira, Jorge CS Costa, Renato SB Cordeiro, Magda F Serra, Patrícia MR e Silva, Marco A Martins   +5 more
doaj   +1 more source

CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma

Cell & Bioscience, 2021
Background Cigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies are needed for CS-associated asthma.
Hongtao Li, Qimei Ye, Yusen Lin, Xuena Yang, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng, Tiantuo Zhang   +8 more
doaj   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Pharmacological profiles of F-1322, a novel anti-asthmatic agent. (1). Mechanisms of action.

Folia Pharmacologica Japonica, 1995
The pharmacological effects of N-[2-(4-(benzhydryloxy)piperidino)ethyl]-3-hydroxy-5-(3-pyridyl methoxy)-2- naphthamide (F-1322), a novel anti-asthmatic agent, was investigated in vitro. The results obtained were as follows: 1) In the isolated trachea of guinea pigs, F-1322 showed a markedly potent antagonistic action against the contraction induced by ...
LEE, Bunsho, TAKASAKI, Kazuhiko, MOCHIZUKI, Akinori, TAMURA, Norihiko, HIGASHIDE, Yasushi, YAMAURA, Tetsuaki   +5 more
openaire   +3 more sources

Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review

Asian Pacific Journal of Tropical Biomedicine, 2017
The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids (BA). The oleo gum resin obtained from Indian variety i.e.
Farah Iram, Shah Alam Khan, Asif Husain
doaj   +1 more source

Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases

Molecules, 2022
The inflammatory response is a central aspect of the human immune system that acts as a defense mechanism to protect the body against infections and injuries.
Juman Mohammed Rasmi Alamil, Keshav Raj Paudel, Yinghan Chan, Dikaia Xenaki, Jithendra Panneerselvam, Sachin Kumar Singh, Monica Gulati, Niraj Kumar Jha, Deepak Kumar, Parteek Prasher, Gaurav Gupta, Raniya Malik, Brian George Oliver, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan   +15 more
doaj   +1 more source