Short-acting β2-agonist prescriptions in patients with asthma: findings from the South Korean cohort of SABINA III [PDF]
The Korean Journal of Internal MedicineBackground/Aims Despite short-acting β2-agonist (SABA) overuse being associated with poor asthma outcomes, data on SABA use in South Korea is scarce.
Kwang-Ha Yoo +6 more
doaj +1 more source
Peripheral Anti-nociceptive and Anti-inflammatory Effect of OleanoliAcid in a Rat Model of Osteoarthritis [PDF]
, 2021 Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechanisms of such effects have not yet
Fouani, Malak +3 more
core +1 more source
Research on and developmental strategy of anti-asthmatic agents
Folia Pharmacologica Japonica, 2008 気管支喘息の基本となる病態が気道の慢性炎症であることから，吸入ステロイド薬を中心とした抗炎症療法の導入は喘息症状のコントロールを可能にし，喘息患者のquality of lifeを飛躍的に向上させた．その一方で，分子レベルでの病態への理解が深まり，特に気道炎症の発症・進展に関わる過程と関連する各種因子の解明が進むことで，より安全で効果的な治療薬の創製に向けた研究開発が試みられている．本稿では，気道炎症の制御を作用メカニズムとした新規喘息治療薬に焦点をあて，その概略を紹介する．
Totsuka, Ryuichi, Kikuchi, Matsuo
openaire +3 more sources
Plants, 2023 Plants of the genus Tylophora have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones.
Ehab M. Mostafa +10 more
doaj +1 more source
, 2021 Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines ...
Turan, Gulhan +10 more
core +1 more source
Serum IgE as a Biomarker of Severity and Short-term Treatment Response in Steroid-naïve Children with Asthma: A Hospital-based Prospective Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Paediatric asthma is a growing public health challenge in Low- and Middle-Income Countries (LMICs), with increasing prevalence and substantial morbidity.
Kishore Alagesan +5 more
doaj +1 more source
Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma [PDF]
, 2013 Peer ...
Walsh, Garry Michael, Walsh GM
core +1 more source
Parent’s perceptions and concerns about inhaled asthma therapy
Gazeta Médica, 2019 Aim: To determine parent´s perceptions and concerns about inhaled therapy and their relation to disease control. Methods: A questionnaire was applied by interviewing parents of 119 asthmatic children attending the Pediatric Allergy or Pneumology ...
Rita Barreira +5 more
doaj +1 more source
Docking analysis and the possibility of prediction efficacy for an anti-IL-13 biopharmaceutical treatment with tralokinumab and lebrikizumab for bronchial asthma. [PDF]
PLoS ONE, 2017 Interleukin-13 (IL-13) is associated with allergic airway inflammation and airway remodeling. Our group found a variant with a single nucleotide polymorphism in the IL13 gene at position +2044G>A (rs20541) that was expected to result in the non ...
Yutaka Nakamura +3 more
doaj +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source