Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio+8 more
core +2 more sources
Methylene blue-containing liposomes as new photodynamic anti-bacterial agents
Novel cationic liposomes containing the photo-activatable drug methylene blue (MB) strongly enhance the antibacterial activity of MB towards Gram-negative bacteria and improve biofilm penetration.
BOCCALINI, GIULIA+8 more
openaire +3 more sources
Differences in reactivation of tuberculosis induced from anti-tnf treatments are based on bioavailability in granulomatous tissue [PDF]
The immune response to Mycobacterium tuberculosis (Mtb) infection is complex. Experimental evidence has revealed that tumor necrosis factor (TNF) plays a major role in host defense against Mtb in both active and latent phases of infection.
Denise E Kirschner+7 more
core +3 more sources
Antibacterial Activity of Methanol Extract of Achillea Wilhe lmsii C. Koch Flower and Leaf [PDF]
Background and Objectives: Infection diseaseshave always been an important concern of human being and attracted theattention of a large number of professionals from the medical and laboratory community.
Amjad L+2 more
doaj
EXPLORATION OF BACTERIA Symbionts Mangrove Waste FOR THE PRODUCTION OF DECOMPOSTER [PDF]
Mangrove waste comprises of naturally decomposed dead mangrove leaves, twigs, and branches. This research aims to determine the types of bacterial symbionts in mangrove waste with potency as anti-bacterial agents.
Azmi, Izzuddin+3 more
core
Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis [PDF]
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood.
A Matlow+88 more
core +1 more source
WHAT IS THE EPIDEMIOLOGICAL PROFILE OF ACUTE HAND INFECTIONS AT A HOSPITAL IN SAO PAULO? [PDF]
Objective: To determine the epidemiological profile of patients treated at a philanthropic hospital specialized in Orthopedics and Traumatology, located in a significant urban center, and evaluate the efficacy of initial empirical antibiotic treatment ...
Thomas Yi Teh Lee+5 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Synthesis and evaluation of troponoids as a new class of antibiotics [PDF]
Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus ...
Adegboyega, Patrick+8 more
core +4 more sources
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source