Results 41 to 50 of about 2,173 (197)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Farmacocinética y farmacodinámica, implicación en un uso más racional de los antimicrobianos en pediatría Pharmacokinetics and pharmacodynamics, implications in the more rational usage of antimicrobials in pediatrics

Revista Médica Electrónica, 2009
La farmacodinámica describe la compleja interrelación que se establece entre el perfil farmacocinético del antimicrobiano y la susceptibilidad in vitro de la bacteria.
Amaury Noda Albelo, Arturo Vidal Tallet
doaj  

Anti-Bacterial Agents, does the losing battle?

Acta Médica del Centro, 2014
The anti-Bacterial Agents are a type of microorganisms that have been able to evade the main antibiotics against them and are designed like a present danger to global warming and climate change for human beings, both morbidity and mortality than in many ...
Leisky Mesa Coello, Oscar Rogelio Estupiñán Martínez, Dianelis Lorelys Reyes Hernández   +2 more
doaj  

Betel leaf extract as an anti-bacterial agent in solid soap formulation and characterisation

Jurnal Pijar Mipa, 2023
Used cooking oil is a waste oil derived from plants used as cooking oil. Used cooking oil can be reused by a purification process and used in soap making by a saponification process using a base (KOH or NaOH). Based on this, waste cooking oil is handled as a raw material for making solid soap.
Rima Wulandari, Ika Kusuma Nugraheni, Mariatul Kiptiah   +2 more
openaire   +2 more sources

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

FEBS Open Bio, EarlyView.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques, Edit Ábrahám, Hiromi Muramatsu, Daniel Youssef Bargieri, Norbert Pardi, Zoltán Lipinszki   +5 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Comparison of Antimicrobial Activity of Chitosan Nanoparticles Loaded with Amoxicillin with Free Amoxicillin against Some Gram Positive and Gram Negative Bacteria

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Antibiotic resistance has prepared the way for substituting new therapeutic methods. Studies have indicated that nanoformulated antimicrobial agents have better therapeutic effects.
Asma Toraji, Mahnaz Hadizadeh, Fahimeh Nemati Mansoor   +2 more
doaj  

Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus

FEBS Open Bio, EarlyView.
The bacterial cell membrane and cell wall are the primary targets of baicalin. Baicalin increases the permeability of bacterial membranes, allowing oxacillin sodium to easily penetrate the cells and effectively exert its antimicrobial activity. Methicillin‐resistant Staphylococcus aureus (MRSA) poses a challenge for clinical treatment and combining ...
Xin Meng, Mengna Kang, Zhiyun Yu, Changyou Li, Yang Chen, Taicheng Jin, Kai Wang, Haiyong Guo   +7 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source