Results 41 to 50 of about 375,460 (285)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Vitellogenin from the Silkworm, Bombyx mori: An Effective Anti-Bacterial Agent

open access: yesPLoS ONE, 2013
Silkworm, Bombyx mori, vitellogenin (Vg) was isolated from perivisceral fat body of day 3 of pupa. Both Vg subunits were co-purified as verified by mass spectrometry and immunoblot. Purified Vg responded to specific tests for major posttranslational modifications on native gels indicating its nature as lipo-glyco-phosphoprotein.
Nitin Kumar Singh   +6 more
openaire   +4 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Physicochemical Characteristics of Nanoliposome Garlic (Allium sativum L.) Essential Oil and Its Antibacterial Effect on Escherichia coli O157:H7 [PDF]

open access: yesJournal of Food Quality and Hazards Control, 2017
Background: Escherichia coli O157:H7 is a Gram-negative and facultative anaerobic food-borne bacterial pathogen. The major purpose of this study was to evaluate physicochemical characteristics of nanoliposome garlic Essential Oil (EO) and its ...
A. Zabihi   +7 more
doaj  

Investigation of antimicrobial activity of silver and copper citrate for the development of pharmaceuticals preparations

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
The fast formation of microbial resistance to antibiotics creates necessity of search for new alternative antimicrobial drugs. Aim. To study the specific antimicrobial activity of silver citrate and copper citrate for the purpose of pharmaceutical ...
Z. N. Polova
doaj   +1 more source

Antimicrobial properties of nanomolecules: potential candidates as antibiotics in the era of multi-drug resistance [PDF]

open access: yesEpidemiology and Health, 2015
OBJECTIVES: The emergence of multi-drug resistance among various microbial pathogens has been a cause of serious concern to the medical world, limiting the choice of antibiotics.
Venkataramana Kandi, Sabitha Kandi
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Dynamics of Antibiotic Prescription in Royal Hampshire County Hospital in November 2016: A Prospective Study

open access: yesInternational Journal of Medical Students, 2017
Background: Antimicrobial Stewardship and The Start Smart – Then Focus strategy provide guidelines aimed at improving the increasing trend of antibiotic resistance.
Kathrine Lee-A-Ping   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pneumococcal Osteomyelitis: Report of One Case

open access: yesPediatrics and Neonatology, 2008
Acute osteomyelitis is uncommon in pediatric patients, affecting one in five thousand children younger than the age of thirteen. Bone infection caused by Streptococcus pneumoniae is extremely rare, accounting for only 1.3% of acute osteomyelitis in ...
W. Luke Huang   +4 more
doaj   +1 more source

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