Results 61 to 70 of about 809 (171)

Immunopathogenesis of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed, Ai, Ai, Anzilotti, Arend, Astorri, Benham, Bombardieri, Bottini, Bottini, Byng-Maddick, Catrina, Catrina, Charles-Schoeman, Christophorou, Corsiero, Croft, de Aquino, de Hair, Deane, Dennis, Diarra, Ekwall, El-Gabalawy, Ferreira, Filer, Firestein, Firestein, Firestein, Firestein, Firestein, Fonseca, Franz, Gary S. Firestein, Genovese, Hammaker, Harre, Hill, Horiuchi, Huber, Iain B. McInnes, Joosten, Juarez, Kaminsky, Karouzakis, Kelly, Kiener, Kim, Kinslow, Kirschmann, Klarenbeek, Konig, Konig, Krishnadas, Krishnamurthy, Källberg, Langley, Law, Lee, Lefèvre, Linn-Rasker, Liu, Lubberts, Lundström, Makrygiannakis, Matsumoto, McInnes, McInnes, McInnes, McInnes, McKellar, Miossec, Mydel, Müller-Ladner, Nakamachi, Nakano, Nakano, Nam, Okada, Pap, Perlman, Pitzalis, Randen, Rawlings, Raychaudhuri, Raza, Reynisdottir, Reynisdottir, Robertson, Rodríguez-Carrio, Rombouts, Rossetti, Scally, Scher, Schiff, Shi, Shi, Smolen, Smolen, Snir, Sokolove, Stanczyk, Suzuki, Tan, Tran, Tsaprouni, van Beers, van der Helm-van Mil, Vassallo, Wang, Wegner, Weyand, Yamamoto, Yang, Zhang, Zvaifler   +115 more
core   +1 more source

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

Arthritis Research & Therapy, 2017
Background Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties.
Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes, Leendert A. Trouw   +8 more
doaj   +1 more source

Pathogenic role of immune cells in rheumatoid arthritis: Implications in clinical treatment and biomarker development [PDF]

, 2018
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern.
Chow, Sook Khuan *, Peh, Suat Cheng *, Tee, Sabrina Zi Yi *, Teow, Sin Yeang *, Wong, Magdelyn Mei Theing *, Yap, Hooi Yeen *   +5 more
core   +1 more source

The importance of early arthritis in patients with rheumatoid arthritis [PDF]

, 2018
Rheumatoid arthritis (RA) is a systemic inflammatory disorder that manifests predominantly in the synovial joint, where it causes a chronic inflammatory process, leading to early osteoarticular destructions.
Diaconu, Camelia C, Hainarosie, Razvan, Iancu, Mihaela A, Iftimie, Georgiana, Isvoranu, Gheorghita, Marcu, Dragos, Neagu, Tiberiu P, Pantea Stoian, Anca, Socea, Bogdan, Stanescu, Ana Maria Alexandra   +9 more
core   +3 more sources

Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis

Mediators of Inflammation, Volume 2019, Issue 1, 2019., 2019
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self‐structures in the serum and synovial fluid. These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen
Qinghua Fang, Jiaxin Ou, Kutty Selva Nandakumar, Antonella Fioravanti   +3 more
wiley   +1 more source

An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
A protein undergoes many types of posttranslation modification. Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. This process depends on catalytic enzymes such as peptidylarginine deiminase enzymes (PADs).
Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan, Cinzia Ciccacci   +7 more
wiley   +1 more source

Disease mechanisms in preclinical rheumatoid arthritis: a narrative review [PDF]

, 2022
Copyright © 2022 Romão and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and ...
Fonseca, João Eurico, Romão, Vasco C.
core   +1 more source

Role of Anti–Carbamylated Protein Antibodies Compared to Anti–Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First‐Degree Relatives, and Healthy Controls

Arthritis &Rheumatology, Volume 68, Issue 9, Page 2090-2098, September 2016., 2016
Objective Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies, including seropositivity for rheumatoid factor (RF) and anti–citrullinated protein antibodies (ACPAs). In addition, antibodies to carbamylated proteins (anti‐CarP) are present in patients with RA and are associated with joint damage.
H. Koppejan, L. A. Trouw, J. Sokolove, L. J. Lahey, T. J. W. Huizinga, I. A. Smolik, D. B. Robinson, H. S. El‐Gabalawy, R. E. M. Toes, C. A. Hitchon   +9 more
wiley   +1 more source

Laboratory diagnostics and pathogenesis of rheumatoid arthritis — the past and the present [PDF]

, 2018
Rheumatoid arthritis (RA) is one of the most common systemic connective tissue diseases of autoimmune origin and is characterised by chronic inflammation of joints. The aetiology of this disease has not been fully understood yet.
Kuligowska-Prusińska, Magdalena, Odrowąż-Sypniewska, Grazyna   +1 more
core   +2 more sources

Improved classification of rheumatoid arthritis with a score including anti‑acetylated ornithine antibodies [PDF]

, 2020
The presence of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) autoantibodies contributes to the current rheumatoid arthritis (RA) classification criteria.
Balsa, Alejandro, Bang, Holger, González, Antonio, González‑Álvaro, Isidoro, Martinez‑Feito, Ana, Nuño, Laura, Ortiz, Ana M., Peiteado, Diana, Regueiro, Cristina, Rodriguez‑Martínez, Lorena, Triguero‑Martinez, Ana, Villalba, Alejandro   +11 more
core   +2 more sources