Anti-Carbamylated Protein Antibodies as a Reproducible Independent Type of Rheumatoid Arthritis Autoantibodies. [PDF]
PLoS ONE, 2016 A large fraction of the patients with rheumatoid arthritis (RA) develop specific autoantibodies, which until recently were only of two types, rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA).
Ariana Montes +5 more
doaj +10 more sources
Anti-carbamylated protein antibodies in systemic sclerosis [PDF]
Arthritis Research & Therapy, 2023 Background To investigate the presence of different isotypes of anti-carbamylated protein (CarP) antibodies in systemic sclerosis (SSc) patients and its association with skin involvement.
Sophie I. E. Liem +8 more
doaj +7 more sources
Value of Measuring Anti-Carbamylated Protein Antibodies for Classification on Early Arthritis Patients [PDF]
Scientific Reports, 2017 Classification of patients with rheumatoid arthritis (RA) as quickly as possible improves their prognosis. This reason motivates specially dedicated early arthritis (EA) clinics.
Cristina Regueiro +9 more
doaj +8 more sources
Anti-carbamylated protein antibodies and skin involvement in patients with systemic sclerosis: An intriguing association. [PDF]
PLoS ONE, 2018 Carbamylation is a post-translational modification that mostly affects proteins with low turnover, such as dermal proteins. Carbamylated proteins accumulate in skin in an age-dependent manner, contributing to tissue alterations.
Elvira Favoino +6 more
doaj +8 more sources
Diagnostics, 2022 (1) Background: Anti-carbamylated protein (CarP) antibodies have been studied as novel markers to aid in the diagnosis and prognosis of rheumatoid arthritis.
Vincent Ricchiuti +6 more
doaj +6 more sources
Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis [PDF]
Arthritis Research & Therapy, 2017 Background Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have
Marije K. Verheul +4 more
doaj +9 more sources
Increased disease activity in early arthritis patients with anti-carbamylated protein antibodies [PDF]
Scientific Reports, 2021 The initial management of rheumatoid arthritis (RA) has a high impact on disease prognosis. Therefore, we need to select the most appropriate treatment as soon as possible. This goal requires biomarkers of disease severity and prognosis.
Cristina Regueiro +10 more
doaj +6 more sources
The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients [PDF]
Arthritis Research & Therapy, 2017 Background Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties.
Myrthe A. M. van Delft +8 more
doaj +6 more sources
Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis [PDF]
BMC Musculoskeletal Disorders, 2022 Objective Rheumatoid arthritis (RA) is often complicated with chronic lung diseases (CLD), including interstitial lung disease (ILD) and airway disease, which occur as extra-articular manifestations.
Shomi Oka +13 more
doaj +2 more sources
Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis. [PDF]
Arthritis RheumatolObjective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Nakabo S +9 more
europepmc +2 more sources