Results 1 to 10 of about 7,359,914 (273)

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load [PDF]

Arthritis Research & Therapy, 2021
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is
Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer, René E. M. Toes   +16 more
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Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis [PDF]

Arthritis Research & Therapy
Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies against modified proteins, known as anti-modified protein autoantibodies (AMPAs).
Tineke J. van Wesemael, Fraser R. Morton, Judith W. Heutz, Marc P. Maurits, Annemarie L. Dorjée, Duncan Porter, Tom W. J. Huizinga, Karim Raza, Rene E. M. Toes, Rachel Knevel, Pascal H. P. de Jong, Anna Svärd, Diane van der Woude   +12 more
doaj   +7 more sources

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications [PDF]

Arthritis Research & Therapy, 2021
Background Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated proteins.
M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes, D. van der Woude   +9 more
doaj   +5 more sources

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities.
Caroline Grönwall, Lisa Liljefors, Holger Bang, Aase H. Hensvold, Aase H. Hensvold, Aase H. Hensvold, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Vijay Joshua, Anna Svärd, Anna Svärd, Ragnhild Stålesen, Philip J. Titcombe, Philip J. Titcombe, Johanna Steen, Luca Piccoli, Natalia Sherina, Cyril Clavel, Elisabet Svenungsson, Elisabet Svenungsson, Iva Gunnarsson, Iva Gunnarsson, Saedis Saevarsdottir, Saedis Saevarsdottir, Alf Kastbom, Guy Serre, Lars Alfredsson, Lars Alfredsson, Vivianne Malmström, Johan Rönnelid, Anca I. Catrina, Anca I. Catrina, Anca I. Catrina, Karin Lundberg, Lars Klareskog, Lars Klareskog, Lars Klareskog   +38 more
doaj   +3 more sources

Anti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides

Diagnostics
Background/Objectives. The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide ...
Isabel Haro, Raul Castellanos-Moreira, Raimon Sanmartí, María José Gómara   +3 more
doaj   +3 more sources

Rapid modification of antibodies on the surface of liposomes composed of high-affinity protein A-conjugated phospholipid for selective drug delivery

Biochemistry and Biophysics Reports, 2021
Antibody-modified liposomes, immuno-liposomes, can selectively deliver encapsulated drug ‘cargos’ to cells via the interaction of cell surface proteins with antibodies.
Susumu Hama, Mika Sakai, Shoko Itakura, Eiji Majima, Kentaro Kogure   +4 more
doaj   +1 more source

Anticitrullinated antibodies recognize rheumatoid arthritis associated T-cell epitopes modified by bacterial L-asparaginase

Central European Journal of Immunology, 2023
Citrullinated proteins and anti-citrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). It has been suggested that during inflammation or dysbiosis, bacteria could initiate production of ACPAs ...
Tsvetelina Batsalova, Ivanka Teneva, Krum Bardarov, Dzhemal Moten, Balik Dzhambazov   +4 more
doaj   +1 more source

Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP. [PDF]

PLoS ONE, 2017
Alexander disease (AxD) is a neurodegenerative disease caused by heterozygous mutations in the GFAP gene, which encodes the major intermediate filament protein of astrocytes.
Ni-Hsuan Lin, Albee Messing, Ming-Der Perng   +2 more
doaj   +1 more source

Non-enzymatic glucosylation induced neo-epitopes on human serum albumin: A concentration based study. [PDF]

PLoS ONE, 2017
Hyperglycaemia induced non enzymatic glycation is accelerated in diabetic patients and aggressively involved in diabetes progression. Human serum albumin (HSA) is the most abundant protein in blood circulation.
Km Neelofar, Zarina Arif, Jamal Ahmad, Khursheed Alam   +3 more
doaj   +1 more source

Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding

Viruses, 2020
Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA).
Lauren E. Gentles, Hongquan Wan, Maryna C. Eichelberger, Jesse D. Bloom   +3 more
doaj   +1 more source