Results 21 to 30 of about 5,298,732 (170)

Anti-Modified Protein Antibodies in Rheumatoid Arthritis: Pathogenic, Protective, or Passive Bystander? [PDF]

Immunol Rev
ABSTRACT The presence of anti‐modified protein antibodies (AMPA) is a hallmark of rheumatoid arthritis (RA). AMPA recognize post‐translationally modified proteins and are cross‐reactive. AMPA include anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA).
Stalman AFL, van der Woude D.
europepmc   +2 more sources

Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. [PDF]

PLoS ONE, 2018
Rheumatoid arthritis (RA) has a negative impact on bone that is partly mediated by anti-citrullinated proteins antibodies (ACPA). These antibodies are associated with erosions, and with juxta-articular and systemic bone loss. Other RA autoantibodies, the
Cristina Regueiro, Ana M Ortiz, Maria Dolores Boveda, Santos Castañeda, Isidoro Gonzalez-Alvaro, Antonio Gonzalez   +5 more
doaj   +2 more sources

Protective and Pathogenic Antibodies to Citrullinated Antigens. [PDF]

Immunol Rev
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Sareila O, He Y, Xu Z, Ge C, Lönnblom E, Holmdahl R.   +5 more
europepmc   +2 more sources

Low mortality rate in Italian rheumatoid arthritis patients from a tertiary center: putative implication of a low anti-carbamylated protein antibodies prevalence [PDF]

Open Access Rheumatology: Research and Reviews, 2018
Daniela Iacono,1 Elvira Favoino,2 Alessia Borgia,1 Serena Fasano,1 Ilenia Pantano,1 Virginia D’Abrosca,1 Giuseppe Picillo,1 Rosa Daniela Grembiale,3 Federico Perosa,2 Gabriele Valentini1 1Department of Clinical and Experimental Medicine ...
Iacono D, Favoino E, Borgia A, Fasano S, Pantano I, D'Abrosca V, Picillo G, Grembiale RD, Perosa F, Valentini G   +9 more
doaj   +2 more sources

Protein carbamylation and proteomics: from artifacts to elucidation of biological functions [PDF]

Frontiers in Analytical Science
Lysine carbamylation is a non-enzymatic protein post-translational modification (PTM) that plays important roles in regulating enzymatic activity and the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, and uremia.
Youngki You, Gina Many, Ernesto S. Nakayasu   +2 more
doaj   +2 more sources

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity. [PDF]

Immunol Rev
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Shrestha C, Weisfelder HM, Do TD.
europepmc   +2 more sources

Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers [PDF]

Rheumatology
Introduction Rheumatoid arthritis (RA) is a prevalent autoimmune disorder characterized by chronic joint inflammation and progressive bone erosion. Traditional autoantibodies, such as anti-citrullinated peptide antibodies (ACPAs) and rheumatoid factor ...
Tomasz Budlewski, Joanna Sarnik, Olga Brzezinska, Anna Lewandowska-Polak, Tomasz Poplawski, Joanna Samanta Makowska   +5 more
doaj   +2 more sources

Anti-carbamylated protein antibodies in ACCP-negative and ACCP-positive patients with rheumatoid arthritis

Научно-практическая ревматология
Objective. Assess the level of antibodies to carbamylated proteins (anti-CarP) and analyse the clinical and immunological associations in patients with ACCP-negative and ACCP-positive variants of rheumatoid arthritis.Materials and methods.
D. A. Dibrov, A. S. Avdeeva, M. E. Diatroptov, E. L. Nasonov   +3 more
doaj   +3 more sources

Rheumatoid Arthritis Diagnostic and Monitoring Testing Patterns by Physicians and Advanced Practice Providers in the United States, 2012 to 2024. [PDF]

ACR Open Rheumatol
Objective To investigate longitudinal trends in rheumatoid arthritis (RA) diagnosis and monitoring by physicians and advanced practice providers (APPs) as measured by laboratory testing. Methods We conducted a retrospective review of RA‐associated diagnostic and monitoring tests ordered through Labcorp by 7,026 physicians and 2,188 APPs in primary care
Lee MK, Lee K, Alfego D, Naides SJ.
europepmc   +2 more sources

Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays [PDF]

Arthritis Research & Therapy
Background Autoantibodies targeting antigens carrying distinct post-translational modifications (PTMs), including citrullinated, carbamylated, and acetylated residues, are characteristic for rheumatoid arthritis (RA).
Roxane Biersteker, Aegli Athanasiadou, Stef van der Meulen, Tineke J. van Wesemael, Linda M. Slot, Theresa Kissel, René E. M. Toes, Leendert A. Trouw, Diane van der Woude   +8 more
doaj   +2 more sources