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The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis. [PDF]

Cent Eur J Immunol, 2017
The most specific autoimmunity known for rheumatoid arthritis (RA) is reflected by generation of anti-citrullinated protein antibodies (ACPA). Presence of ACPA in established RA is associated with disease severity, while generation of ACPA at early developmental phases of RA can have a strong predictive value for progressing to the full-blown disease ...
Kurowska W, Kuca-Warnawin EH, Radzikowska A, Maśliński W.   +3 more
europepmc   +4 more sources

Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients

Frontiers in Immunology, 2023
Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients.
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng   +9 more
doaj   +3 more sources

Diagnostic Performance of the Multi-Biomarker Disease Activity (MBDA) Score for Rheumatoid Arthritis in Patients with New-Onset Joint Symptoms: An Age-Stratified Retrospective Study [PDF]

Open Access Rheumatology: Research and Reviews
Kazuya Hiura,1 Moeko Ito,1 Yuka Shimizu,2 Tsuyoshi Takeda,3 Sachiko Iwaki-Egawa1 1Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Japan; 2Department of Gastroenterology, Obihiro Kosei General Hospital, Obihiro, Japan ...
Hiura K, Ito M, Shimizu Y, Takeda T, Iwaki-Egawa S   +4 more
doaj   +2 more sources

Relationship between anti-Epstein-Barr virus early antigen diffuse type and restricted type immunoglobulin G antibodies and disease activity and autoantibodies in rheumatoid arthritis: a retrospective observational study [PDF]

BMC Rheumatology
Background This study examined to examine the relationship of Epstein-Barr virus (EBV) in rheumatoid arthritis (RA) by evaluating disease activity and autoantibody levels in positive and negative cases using the anti-EBV early antigen diffuse type and ...
Noboru Kitamura, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Hideki Nakamura   +4 more
doaj   +2 more sources

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Frontiers in Immunology, 2022
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Aase Hensvold, Gunnar Johannsen, Gunnar Johannsen, Kaja Eriksson, Kaja Eriksson, Federica Sallusto, Federica Sallusto, Anca I. Catrina, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg   +36 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA.
Adrienn Markovics, Tímea Ocskó, Robert S Katz, Edit I Buzás, Tibor T Glant, Katalin Mikecz   +5 more
doaj   +1 more source

Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays

Scientific Reports, 2021
The presence or absence of autoantibodies against citrullinated proteins (ACPAs) distinguishes two main groups of rheumatoid arthritis (RA) patients with different etiologies, prognoses, disease severities, and, presumably, disease pathogenesis.
Thomas B. G. Poulsen, Dres Damgaard, Malene M. Jørgensen, Ladislav Senolt, Jonathan M. Blackburn, Claus H. Nielsen, Allan Stensballe   +6 more
doaj   +1 more source

Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

Antibodies, 2022
Rheumatoid arthritis (RA) is a chronic disease which causes joint inflammation and, ultimately, erosion of the underlying bone. Diagnosis of RA is based on the presence of biomarkers, such as anti-citrullinated protein antibodies (ACPA) and rheumatoid ...
Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Jette Lautrup Frederiksen, Gunnar Houen, Nicole Hartwig Trier   +5 more
doaj   +1 more source

Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?

Clinical & Translational Immunology, 2021
Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management.
Leonor Nogueira, Emilie Parra, Margaux Larrieu, Evelyne Verrouil, Martin Cornillet   +4 more
doaj   +1 more source