Citrullinated peptides as drug candidates for rheumatoid arthritis [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) involves a breakdown of immune tolerance to citrullinated proteins, leading to chronic inflammation and joint damage. Despite advances in treatment, achieving long-term remission remains a major challenge.
Tue Wenzel Kragstrup +2 more
exaly +6 more sources
Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort [PDF]
Pediatric RheumatologyBackground Juvenile idiopathic arthritis is a heterogeneous group of chronic inflammatory joint diseases in children. The presence and role of antibodies targeting citrullinated proteins remains unclear in this patient group.
Karin Lundberg +2 more
exaly +3 more sources
Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque [PDF]
Frontiers in Immunology, 2017 ObjectivesAnti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established.
Samuel Bitoun +10 more
doaj +2 more sources
Antibodies, 2021 Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1–2% of the world population. In addition to the first discovered serologic markers for RA, the rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs) are even ...
Paul Robert Hansen +2 more
exaly +3 more sources
Citrullinated peptides of peptidyl arginine deiminase 4 as major B-cell epitopes in patients with rheumatoid arthritis [PDF]
Frontiers in ImmunologyObjectiveTo identify new autoantibodies in rheumatoid arthritis (RA) patients’ sera.MethodsWe tested serum samples from 55 patients with RA and 25 controls on arrays containing 188 peptides from the alpha and beta chains of fibrinogen, vimentin, histon 4,
Mathilde Giassi +4 more
doaj +2 more sources
Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients? [PDF]
Clinical & Translational Immunology, 2021 Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management.
Leonor Nogueira +4 more
doaj +2 more sources
Development of a multiplex assay based on chimeric citrullinated peptides as proof of concept for diagnosis of rheumatoid arthritis. [PDF]
PLoS ONE, 2019 Anti-citrullinated peptide/protein antibodies (ACPAs) are the most specific serological biomarkers for rheumatoid arthritis (RA). They have both diagnostic and prognostic value, and are related to more aggressive joint disease in RA.
Cristina García-Moreno +4 more
doaj +2 more sources
Presence of autoantibodies targeting the shared epitope in rheumatoid arthritis and psoriatic arthritis [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is an autoimmune disease marked by the production of autoantibodies (AAb) against citrullinated proteins/peptides (ACPA).
Eduard Graell +22 more
doaj +2 more sources
Epitope Specificity of Anti-Citrullinated Protein Antibodies
Antibodies, 2017 Anti-citrullinated protein antibodies are primarily associated with a progressive course in the autoimmune disease rheumatoid arthritis, a disease with a chronic and inflammatory nature.
Gunnar Houen +2 more
exaly +3 more sources
The rheumatoid arthritis citrullinome is enriched in antigenic complement proteins [PDF]
Arthritis Research & TherapyObjectives Citrullination is a post-translational modification that serves as an autoantigen in Rheumatoid Arthritis (RA). It remains unclear whether there is an excess production of specific citrullinated proteins in RA patients that is driving the ...
Mario Navarrete +13 more
doaj +2 more sources