Results 11 to 20 of about 6,340 (217)

Contribution of Peptide Backbone to Anti-Citrullinated Peptide Antibody Reactivity.

PLoS ONE, 2015
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1-2% of the world population. One of the characteristic features of RA is the presence of autoantibodies.
Nicole Hartwig Trier, Catharina Essendrup Dam, Dorthe Tange Olsen, Paul Robert Hansen, Gunnar Houen   +4 more
doaj   +4 more sources

Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice [PDF]

Particle and Fibre Toxicology
Silicosis remains a critical occupational health concern worldwide, lacking effective treatments due to unclear mechanisms. In this study, we investigated the citrullinated proteomic profile and its effects in mice exposed to silica.
Fuyu Jin, Yaqian Li, Tian Li, Shupeng Liu, Dingjie Xu, Heliang Liu, Zhongqiu Wei, Xuemin Gao, Na Mao, Wenchen Cai, Yiwei Shi, Haibo Zhang, Hong Xu   +12 more
doaj   +2 more sources

The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance [PDF]

Journal of Experimental Medicine, 2023
Shawn A Mahmud, Marc Jenkins, Thamotharampillai Dileepan   +2 more
exaly   +2 more sources

Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF [PDF]

Clinical Rheumatology, 2016
Min Xu, Jianning Zhao, Xiao-Jun Li
exaly   +2 more sources

Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

Antibodies, 2022
Rheumatoid arthritis (RA) is a chronic disease which causes joint inflammation and, ultimately, erosion of the underlying bone. Diagnosis of RA is based on the presence of biomarkers, such as anti-citrullinated protein antibodies (ACPA) and rheumatoid ...
Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Jette Lautrup Frederiksen, Gunnar Houen, Nicole Hartwig Trier   +5 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis.

PLoS ONE, 2022
The immune response to citrullinated peptides in the mucosa has been suggested to play an important role in the transition from pre-onset rheumatoid arthritis (RA) to clinically evident RA.
Takuya Yasuda, Koichiro Tahara, Tetsuji Sawada   +2 more
doaj   +2 more sources

Antibodies to citrullinated peptides in tuberculosis [PDF]

Clinical Rheumatology, 2013
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF.
I, Lima, R C, Oliveira, A, Atta, S, Marchi, L, Barbosa, E, Reis, M G, Reis, M B, Santiago   +7 more
openaire   +2 more sources

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

Frontiers in Immunology, 2021
BackgroundSomatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline.
Peter Symonds, Ana Marcu, Ana Marcu, Katherine W. Cook, Rachael L. Metheringham, Lindy G. Durrant, Lindy G. Durrant, Victoria A. Brentville   +7 more
doaj   +1 more source

The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

PLoS ONE, 2021
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins.
Stephane Becart, Karen B Whittington, Amanda Prislovsky, Navin L Rao, Edward F Rosloniec   +4 more
doaj   +1 more source