Results 1 to 10 of about 7,385 (114)
Citrullination only infrequently impacts peptide binding to HLA class II MHC [PDF]
PLoS ONE, 2017 It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination.
Alessandro Sette +2 more
exaly +2 more sources
Beyond PAD Inhibition: Emerging Avenues and Natural Products for Targeting Citrullination in Immune Diseases [PDF]
BiomedicinesImmune-mediated inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, impose a severe and growing global health burden, where current therapies are limited by poor specificity and significant side ...
Qilei Chen +7 more
doaj +2 more sources
Citrullination in health and disease: From physiological function to gene regulation
Genes and DiseasesProtein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases.
Lang Rao, Chaoguang Tian
exaly +3 more sources
Citrullination in tumor immunity and therapy [PDF]
The Journal of Clinical InvestigationPeptidyl arginine deiminases (PADs) catalyze the conversion of arginine residues into peptidyl citrulline, a posttranslational modification known as protein citrullination (or arginine deimination).
Michael R. Pitter, Weiping Zou
doaj +2 more sources
Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response [PDF]
iScienceSummary: SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replication and inflammation.
Selina Pasquero +20 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2023 Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis (RA), but the relationship between the two phenomena remains unclear. We explored whether and how cholinergic dysfunction accelerates protein citrullination
Changjun Lv +12 more
doaj +1 more source
The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases
Journal of Innate Immunity, 2022 Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
doaj +1 more source
Histone citrullination: a new target for tumors
Molecular Cancer, 2021 As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and ...
Dongwei Zhu, Yue Zhang, Shengjun Wang
doaj +1 more source
Inflammation-related citrullination of matrisome proteins in human cancer
Frontiers in Oncology, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu +3 more
doaj +1 more source
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination
Journal of Immunology Research, 2021 The aberrant upregulation of protein arginine deiminase 2- (PAD2-) catalyzed citrullination is reported in various autoimmune diseases (rheumatoid arthritis and multiple sclerosis) and several cancers.
Masayoshi Aosasa +8 more
doaj +1 more source