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Progression on Citrullination of Proteins in Gastrointestinal Cancers [PDF]
Frontiers in Oncology, 2019 The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis.
Shuzheng Song, Yingyan Yu, Yu Yingyan
exaly +4 more sources
Citrullination and autoimmunity
Autoimmunity Reviews, 2015 Autoimmune diseases are characterized by the body's own immune system attack to the self-tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance.
Guido Valesini +2 more
exaly +5 more sources
The role of SERPIN citrullination in thrombosis
Cell Chemical Biology, 2021 Aberrant protein citrullination is associated with many pathologies, however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in Rheumatoid ...
Ronak Tilvawala +2 more
exaly +5 more sources
Citrullination in health and disease: From physiological function to gene regulation
Genes and DiseasesProtein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases.
Lang Rao, Chaoguang Tian
exaly +4 more sources
Histone citrullination: a new target for tumors
Molecular Cancer, 2021 As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and ...
Dongwei Zhu, Yue Zhang, Shengjun Wang
doaj +2 more sources
Frontiers in Immunology, 2020 Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova +9 more
doaj +3 more sources
Acta Pharmaceutica Sinica B, 2023 Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis (RA), but the relationship between the two phenomena remains unclear. We explored whether and how cholinergic dysfunction accelerates protein citrullination
Changjun Lv, Yilei Guo, Simiao Qiao
exaly +3 more sources
Citrullination only infrequently impacts peptide binding to HLA class II MHC [PDF]
PLoS ONE, 2017 It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination.
John Sidney +2 more
exaly +2 more sources
Joint inflammation related citrullination of functional arginines in extracellular proteins [PDF]
Scientific Reports, 2017 We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose ...
Kalle H. Sipilä +9 more
doaj +3 more sources
Citrullination and autophagy [PDF]
, 2017 During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive.
Guido Valesini +5 more
core +2 more sources