Results 31 to 40 of about 9,594 (224)

PAD4 takes charge:Detection and quantification of protein citrullination [PDF]

Citrullination comprises the enzymatic modification of peptidylarginine to peptidylcitrulline by peptidyl arginine deiminase (PAD) enzymes. The role of citrullination in innate immunity has particularly sparked scientific interest after the finding that ...
Arfman, T.N.
core   +4 more sources

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Citrullination in health and disease: From physiological function to gene regulation

Genes and Diseases
Protein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases.
Xiaoya Zhang, Guiqiu Xie, Lang Rao, Chaoguang Tian   +3 more
doaj   +1 more source

Biosynthesis of Citrulline in Plants [PDF]

Nature, 1961
IN 1930 citrulline was discovered in water-melons1. Later it was shown to be an important participant in the Krebs and Henseleit ornithine cycle in animals and micro-organisms. In recent years several laboratories have worked on the ornithine cycle in plants.
openaire   +2 more sources

Citrullination Site Prediction by Incorporating Sequence Coupled Effects into PseAAC and Resolving Data Imbalance Issue

, 2020
Background: Post-translational modification is one of the bio-molecular mechanisms in living organisms, which incorporate functional diversity in proteins as well as regulate cellular processes. Transformation of arginine residue to citrulline in protein
Ahmad, Shamim, Ben Islam, Md Khaled, Hasan, Md Al Mehedi, Rahman, Julia   +3 more
core   +1 more source

Detection and quantification of citrullinated chemokines. [PDF]

PLoS ONE, 2011
BackgroundPosttranslational deimination or citrullination by peptidylarginine deiminases (PAD) regulates the biological function of proteins and may be involved in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Eva A V Moelants, Jo Van Damme, Paul Proost   +2 more
doaj   +1 more source

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

Frontiers in Immunology, 2021
Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis.
María Teresa Martín Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Šenolt, Niels Ødum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Claus H. Nielsen, Dres Damgaard   +10 more
doaj   +1 more source

Determination of Citrulline in Plasma

Clinical Chemistry, 1960
Abstract The Archibald method for the determination of plasma citrulline has been modified to eliminate the dialysis step in order to separate citrulline from plasma proteins. Instead these are precipitated with picric acid and the picrate ion removed by passage through an anion exchange column.
M P, MOCKLER, L R, MENEBROKER, F L, HUMOLLER, A J, BARAK   +3 more
openaire   +2 more sources

Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Cells, 2022
Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE.
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti   +8 more
doaj   +1 more source