Results 31 to 40 of about 1,964 (177)

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
doaj   +1 more source

Protein citrullination: A proposed mechanism for pathology in traumatic brain injury

Frontiers in Neurology, 2015
Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer’s disease, multiple sclerosis (MS) and prion disease.
Rachel C Lazarus, John E Buonora, Michael N Flora, James G Freedy, Gay R Holstein, Giorgio P Martinelli, David M Jacobowitz, David M Jacobowitz, Gregory P Mueller, Gregory P Mueller, Gregory P Mueller   +10 more
doaj   +1 more source

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Citrullination Site Prediction by Incorporating Sequence Coupled Effects into PseAAC and Resolving Data Imbalance Issue

, 2020
Background: Post-translational modification is one of the bio-molecular mechanisms in living organisms, which incorporate functional diversity in proteins as well as regulate cellular processes. Transformation of arginine residue to citrulline in protein
Ahmad, Shamim, Ben Islam, Md Khaled, Hasan, Md Al Mehedi, Rahman, Julia   +3 more
core   +1 more source

Citrullination of Amyloid Peptides in Alzheimers Disease

, 2021
Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains.
Catriona McLean (659190), Qiao-Xin Li, Keyla A. Perez (11431501), Kevin J. Barham, Blaine R. Roberts (1578931), Shiji Varghese, Blaine R. Roberts, Soumya Mukherjee (1406128), Celine Dubois (11431504), Kevin J. Barham (11431513), Victor A. Streltsov (2659339), Victor A. Streltsov, Qiao-Xin Li (31157), Shiji Varghese (291775), Laura J. Vella, Soumya Mukherjee, Ian Birchall, Rebecca M. Nisbet, Laura J. Vella (8168928), Catriona McLean, Colin L. Masters, Liang Jin, Rebecca M. Nisbet (11431507), Keyla A. Perez, Liang Jin (316008), Ian Birchall (11431510), Celine Dubois, Colin L. Masters (31155)   +27 more
core   +1 more source

Biosynthesis of Citrulline in Plants [PDF]

Nature, 1961
IN 1930 citrulline was discovered in water-melons1. Later it was shown to be an important participant in the Krebs and Henseleit ornithine cycle in animals and micro-organisms. In recent years several laboratories have worked on the ornithine cycle in plants.
openaire   +2 more sources

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

Frontiers in Immunology, 2021
Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis.
María Teresa Martín Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Šenolt, Niels Ødum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Claus H. Nielsen, Dres Damgaard   +10 more
doaj   +1 more source

Protein citrullination: inhibition, identification and insertion

, 2023
Protein citrullination is a post-translational modification (PTM) that is catalysed by the protein arginine deiminase (PAD) family of enzymes. This PTM involves the transformation of an arginine residue into citrulline.
Barasa, Leonard, Thompson, Paul R
core   +1 more source

Detection and quantification of citrullinated chemokines. [PDF]

PLoS ONE, 2011
BackgroundPosttranslational deimination or citrullination by peptidylarginine deiminases (PAD) regulates the biological function of proteins and may be involved in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Eva A V Moelants, Jo Van Damme, Paul Proost   +2 more
doaj   +1 more source

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Frontiers in Cellular and Infection Microbiology, 2022
Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the ...
Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong, Sheri-Ann Tan   +8 more
doaj   +1 more source