Results 41 to 50 of about 9,594 (224)

Citrullination of Amyloid Peptides in Alzheimers Disease

, 2021
Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains.
Catriona McLean (659190), Qiao-Xin Li, Keyla A. Perez (11431501), Kevin J. Barham, Blaine R. Roberts (1578931), Shiji Varghese, Blaine R. Roberts, Soumya Mukherjee (1406128), Celine Dubois (11431504), Kevin J. Barham (11431513), Victor A. Streltsov (2659339), Victor A. Streltsov, Qiao-Xin Li (31157), Shiji Varghese (291775), Laura J. Vella, Soumya Mukherjee, Ian Birchall, Rebecca M. Nisbet, Laura J. Vella (8168928), Catriona McLean, Colin L. Masters, Liang Jin, Rebecca M. Nisbet (11431507), Keyla A. Perez, Liang Jin (316008), Ian Birchall (11431510), Celine Dubois, Colin L. Masters (31155)   +27 more
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Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
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Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Frontiers in Cellular and Infection Microbiology, 2022
Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the ...
Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong, Sheri-Ann Tan   +8 more
doaj   +1 more source

Table_1_Inflammation-related citrullination of matrisome proteins in human cancer.xlsx

, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419), Pekka Rappu (133059), Jyrki Heino (133094), Ujjwal Suwal (14202644)   +3 more
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Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits

Frontiers in Immunology, 2015
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis had a huge impact on studies aimed at understanding autoimmunity in this disease.
Ger J.M. Pruijn
doaj   +1 more source

Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination

Cell Death and Disease, 2023
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone formation and homeostasis remain unknown.
Hyun-Jung Kim, Hye-Rim Shin, Heein Yoon, Min-Sang Park, Byung-Gyu Kim, Jae-I Moon, Woo-Jin Kim, Seung Gwa Park, Ki-Tae Kim, Ha-Neui Kim, Je-Yong Choi, Hyun-Mo Ryoo   +11 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Study on the role of protein deiminases in the nervous system [PDF]

, 2011
"Study on the role of protein deiminases in the nervous system" Citrullination (deimination) is the conversion of protein-bound arginine to citrulline. Citrullination is catalyzed by a family of calcium-dependent enzymes, the peptidylarginine deiminases (
MILLARTE, VALENTINA
core  

Exacerbation of symptomatic arthritis by cigarette smoke in experimental arthritis.

PLoS ONE, 2020
IntroductionEpidemiologically, cigarette smoking is a well-known risk factor for the pathogenesis of rheumatoid arthritis (RA). However, there has been few plausible explanations why cigarette smoking aggravated RA.
Jaewoo Kang, Sang Hoon Jeong, Kijun Lee, Narae Park, Hyerin Jung, Kyuhong Lee, Ji Hyeon Ju   +6 more
doaj   +1 more source

The virtues and vices of protein citrullination

Royal Society Open Science, 2022
The post-translational modification of proteins expands the regulatory scope of the proteome far beyond what is achievable through genome regulation. The field of protein citrullination has seen significant progress in the last two decades.
Maria A. Christophorou
doaj   +1 more source