Results 41 to 50 of about 1,964 (177)

Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Cells, 2022
Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE.
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti   +8 more
doaj   +1 more source

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model.

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Saralili Dipa Robertson, Nidhi eSofat, Robertson, Saralili D, Baines, DL, Wait, R, Robertson, SD, Wait, Robin, Robin eWait, Emma Harriet Baker, Baines, Deborah L, Deborah eBaines, Deborah L. Baines, Sofat, N, Baker, EH, Nidhi Sofat, Saralili D. Robertson, Emma H. Baker, Sofat, Nidhi, Baker, Emma H, Robin Wait   +19 more
core   +1 more source

Table_1_Inflammation-related citrullination of matrisome proteins in human cancer.xlsx

, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419), Pekka Rappu (133059), Jyrki Heino (133094), Ujjwal Suwal (14202644)   +3 more
core   +1 more source

Citrullination and carbamylation in the pathophysiology of rheumatoid arthritits

Frontiers in Immunology, 2015
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis had a huge impact on studies aimed at understanding autoimmunity in this disease.
Ger J.M. Pruijn
doaj   +1 more source

Table_2_Inflammation-related citrullination of matrisome proteins in human cancer.xlsx

, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419), Pekka Rappu (133059), Jyrki Heino (133094), Ujjwal Suwal (14202644)   +3 more
core   +1 more source

Determination of Citrulline in Plasma

Clinical Chemistry, 1960
Abstract The Archibald method for the determination of plasma citrulline has been modified to eliminate the dialysis step in order to separate citrulline from plasma proteins. Instead these are precipitated with picric acid and the picrate ion removed by passage through an anion exchange column.
M P, MOCKLER, L R, MENEBROKER, F L, HUMOLLER, A J, BARAK   +3 more
openaire   +2 more sources

Seeing Citrulline: Development of a Phenylglyoxal-Based Probe To Visualize Protein Citrullination [PDF]

Journal of the American Chemical Society, 2012
Protein arginine deiminases (PADs) catalyze the hydrolysis of peptidyl arginine to form peptidyl citrulline. Abnormally high PAD activity is observed in a host of human diseases, but the exact role of protein citrullination in these diseases and the identities of specific citrullinated disease biomarkers remain unknown, largely because of the lack of ...
Bicker, Kevin L., Subramanian, Venkataraman, Chumanevich, Alexander A., Hofseth, Lorne J., Thompson, Paul R   +4 more
openaire   +3 more sources

Exacerbation of symptomatic arthritis by cigarette smoke in experimental arthritis.

PLoS ONE, 2020
IntroductionEpidemiologically, cigarette smoking is a well-known risk factor for the pathogenesis of rheumatoid arthritis (RA). However, there has been few plausible explanations why cigarette smoking aggravated RA.
Jaewoo Kang, Sang Hoon Jeong, Kijun Lee, Narae Park, Hyerin Jung, Kyuhong Lee, Ji Hyeon Ju   +6 more
doaj   +1 more source

Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination

Cell Death and Disease, 2023
Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of PADI2 in bone formation and homeostasis remain unknown.
Hyun-Jung Kim, Hye-Rim Shin, Heein Yoon, Min-Sang Park, Byung-Gyu Kim, Jae-I Moon, Woo-Jin Kim, Seung Gwa Park, Ki-Tae Kim, Ha-Neui Kim, Je-Yong Choi, Hyun-Mo Ryoo   +11 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source