Results 51 to 60 of about 1,964 (177)

Mining the Human Tissue Proteome for Protein Citrullination

, 2018
Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations, and while the modification has been linked to ...
Dongxue Wang, Tobias Schmidt, Mathias Uhlén, Fredrik Pontén, Hahne, Hannes,, Mathias Wilhelm, Pontén, Fredrik,, Kuster, Bernhard,, Reimer, Ulf,, Chien-Yun Lee, Schmidt, Tobias,, Wang, Dongxue,, Wilhelm, Mathias,, Uhlen, Mathias,, Hannes Hahne, Bernhard Kuster, Karsten Schnatbaum, Ulf Reimer, Schnatbaum, Karsten,, Zolg, Daniel P.,, Lee, Chien-Yun,, Daniel P. Zolg   +21 more
core   +2 more sources

PCSPred_SC: Prediction of Protein Citrullination Sites Using an Effective Sequence-Based Combined Method

IEEE Access, 2020
As one of post-translational modifications (PTMs), protein citrullination is crucial in a diverse array of cellular processes and implicated in a slew of human pathology.
Lina Zhang, Jingui Chen, Chengjin Zhang, Rui Gao, Runtao Yang   +4 more
doaj   +1 more source

Role of PAD enzymes on histone citrullination in cancer

Medical Journal of Babylon, 2022
Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system.
Noor Mohammed Abdulrahman, Shatha Hussein Ali   +1 more
doaj   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Nature Communications
Citrullination plays an essential role in various physiological or pathological processes, however, whether citrullination is involved in regulating tumour progression and the potential therapeutic significance have not been well explored.
Rui Chen, Zhiyuan Lin, Shengqi Shen, Chuxu Zhu, Kai Yan, Caixia Suo, Rui Liu, Haoran Wei, Li Gao, Kaixiang Fan, Huafeng Zhang, Linchong Sun, Ping Gao   +12 more
doaj   +1 more source

Image_1_Inflammation-related citrullination of matrisome proteins in human cancer.jpeg

, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419), Pekka Rappu (133059), Jyrki Heino (133094), Ujjwal Suwal (14202644)   +3 more
core   +1 more source

Citrullination of Self‐Proteins and Autoimmunity [PDF]

Scandinavian Journal of Immunology, 2004
AbstractCitrullination (deimination is an enzymatic, posttranslational conversion of arginine residues to citrulline residues) of joint‐associated self‐proteins may be a possible mechanism in the induction of autoimmune CD4 T‐cell responses in rheumatoid arthritis.
B, Rubin, G, Sønderstrup
openaire   +2 more sources

Laser‐Induced Periodic Phase‐Transition of 2D‐MoTe2 Nanograting Template for Frequency‐Shift Digital‐SERS Immunoassay of Autoimmune Disease

Advanced Science, EarlyView.
A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao, Lulu Cao, Xiaolin Sun, Qiang Wang, Zhiyang Xu, Tianrui Zhai, Yan Zhao, Yijian Jiang, Zhanguo Li, Yinzhou Yan   +9 more
wiley   +1 more source

Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA

Frontiers in Immunology, 2023
IntroductionMZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it interacts with the tail piece of IgM and IgA heavy chain and promotes ...
Benjamin Geary, Bo Sun, Bo Sun, Ronak R. Tilvawala, Leonard Barasa, Konstantin Tsoyi, Ivan O. Rosas, Paul R. Thompson, I-Cheng Ho, I-Cheng Ho   +9 more
doaj   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source