Results 71 to 80 of about 7,469 (193)

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility

Cell Reports, 2018
Summary: Recent proteome analyses have provided a comprehensive overview of various posttranslational modifications (PTMs); however, PTMs involving protein citrullination remain unclear. We performed a proteomic analysis of citrullinated proteins, and we
Chizu Tanikawa, Koji Ueda, Akari Suzuki, Aritoshi Iida, Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Gen Sobue, Naomi Saichi, Yukihide Momozawa, Yoichiro Kamatani, Michiaki Kubo, Kazuhiko Yamamoto, Yusuke Nakamura, Koichi Matsuda   +14 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Exploring Neutrophil Extracellular Traps in Canine Soft Tissue Sarcomas: A Preliminary Study With Translational Insights

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Neutrophil Extracellular Traps (NETs) in Canine Soft Tissue Sarcomas This study investigated the presence of neutrophil extracellular traps (NETs) in canine soft tissue sarcomas using dual immunohistochemistry for citrullinated histone‐3 and myeloperoxidase.
Burak Yildirim, Volkan Ipek
wiley   +1 more source

Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination

Frontiers in Immunology, 2018
Protein citrullination catalyzed by peptidyl arginine deiminase (PADs) is involved in autoimmune disease pathogenesis, especially in rheumatoid arthritis.
Yebin Zhou, Nanette Mittereder, Gary P. Sims   +2 more
doaj   +1 more source

Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres, Marijn J. Hollander, Kimberly M. Bonger   +2 more
wiley   +1 more source

Large‐Scale Autoantibody Reactome Analysis Reveals Shared and Specific Signatures Across Different Immune‐Mediated Inflammatory Diseases

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective The shared and disease‐specific mechanisms across the immune‐mediated inflammatory diseases (IMIDs) spectrum remains incompletely characterized, despite the recognized role of autoantibodies as important indicators of immune tolerance breakdown and immune dysregulation. Methods Autoantibody reactome profiling of IgG and IgA autoantibodies was
Zhou Bai, Bomiao Yu, Zimo Wei, Pancheng Xiao, Minghua Zhan, Mansheng Li, Fang Wang, Yongjing Cheng, Minshu Zhao, Chao Zhang, Xuan Zhang, Xiaobo Yu, Yudong Liu   +12 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi, Mahmoud Mahmoudi, Sina Mozaffari‐Jovin, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Jafar Hajavi, Hanieh Kolahdooz, Seyed‐Alireza Esmaeili   +8 more
wiley   +1 more source

Neutrophil Extracellular Traps Exacerbate UVB‐Induced Photodamage in HaCaT Cells and Mouse Skin via CCDC25/MAPK Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
Neutrophil extracellular traps (NETs) play a pivotal role in UVB‐induced skin photodamage. Mechanistically, NETs bind to the CCDC25 receptor on keratinocytes and subsequently activate the intracellular p‐JNK/JNK signaling pathway, thereby exacerbating skin photodamage.
Yang Zou, Junzhi Li, Yuting Peng, Rui Hu, Ruolin Li, Aijun Chen   +5 more
wiley   +1 more source

Neutrophil extracellular traps induced by activated platelets as a cause of neutrophil–platelet aggregation in β‐thalassaemia/haemoglobin E patients

British Journal of Haematology, Volume 209, Issue 2, Page 703-717, August 2026.
Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed, Rattanaporn Praneetponkang, Potchaman Sittipaisankul, Chayada Thiengtavor, Suwathida Chumpuchanaphai, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Duncan R. Smith, Saovaros Svasti, Pornthip Chaichompoo   +11 more
wiley   +1 more source