Results 81 to 90 of about 9,594 (224)

Peptidyl arginine deiminases: detection and functional analysis of protein citrullination

, 2019
Citrullination is a post-translational modification of arginine that is catalyzed by the protein arginine deiminases (PADs). Abnormal citrullination is observed in many autoimmune diseases and cancers.
Thompson, Paul R, Tilvawala, Ronak
core   +1 more source

Inhibiting citrullination in rheumatoid arthritis: Taking fuel from the fire [PDF]

, 2012
Citrullination is a post-translational modification catalysed by peptidylarginine deiminase and is a common feature of inflammation. The presence of anti-citrullinated protein/peptide antibodies (ACPA), however, is unique to rheumatoid arthritis. Several
Venables, Patrick J, Fisher, BAC, Fisher, BA, Venables, PJ, Fisher, Benjamin Ac   +4 more
core   +1 more source

Citrullination unravels stem cells

, 2014
Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones.
Thompson, Paul R., Venkataraman Subramanian, Subramanian, Venkataraman, Paul R Thompson, Daniel J Slade, Slade, Daniel J.   +5 more
core   +1 more source

Table S1. Compounds mixtures (ten-in-one) information. from Small molecule activates citrullination through targeting PAD2

, 2023
Citrullination is a post-translational modification catalysed by peptidyl arginine deiminase (PAD) enzymes, dysregulation of protein citrullination is involved in various pathological disorders.
Kaiyan Su (16887665), Yirong Zhang (420335), Huimin Zhu (1700296), Xue Zhang (166886), Yi Qu (262233), Xisong Ke (16887668), Mengzhen Shen (16887662), Min Yang (146229), Junjie Zhang (355622), Wei Fu (176366)   +9 more
core   +1 more source

PAD2 Dysregulation and Abnormal Protein Citrullination in ALS Disease Models [PDF]

, 2020
Poster presented virtually at the 25th Annual University of Massachusetts Medical School Research Retreat 2020 on October 26, 2020.Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disease characterized by loss of motor neurons, paralysis
Yusuf, Issa, Thompson, Paul R, Xu, Zuoshang, Qiao, Tao, Tilvawala, Ronak   +4 more
core   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Structural and functional studies of protein citrullination

, 2023
Bei der posttranslationalen Modifikation Citrullinierung werden Argininreste in Proteinen in Citrullinreste umgewandelt. Diese Umwandlung wird durch die Enzyme Peptidylarginin-Deiminasen katalysiert, die an vielen physiologischen Prozessen beteiligt sind.
Grißmann, Melanie
core   +2 more sources

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility

Cell Reports, 2018
Summary: Recent proteome analyses have provided a comprehensive overview of various posttranslational modifications (PTMs); however, PTMs involving protein citrullination remain unclear. We performed a proteomic analysis of citrullinated proteins, and we
Chizu Tanikawa, Koji Ueda, Akari Suzuki, Aritoshi Iida, Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Gen Sobue, Naomi Saichi, Yukihide Momozawa, Yoichiro Kamatani, Michiaki Kubo, Kazuhiko Yamamoto, Yusuke Nakamura, Koichi Matsuda   +14 more
doaj   +1 more source

Peri‐implantitis and systemic inflammation: Current evidence, biological plausibility, and research gaps

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is a biofilm‐associated inflammatory condition characterized by peri‐implant mucosal inflammation and progressive bone loss. The prevalence of peri‐implantitis continues to rise among patients with dental implants. Although peri‐implantitis and periodontitis share similar inflammatory phenotypes, histopathological ...
Yumeng Yan, Jeanie Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source