Results 1 to 10 of about 8,135 (207)

PAD4 and Its Inhibitors in Cancer Progression and Prognosis

Pharmaceutics, 2022
The systemic spread of malignancies and the risk of cancer-associated thrombosis are major clinical challenges in cancer therapy worldwide. As an important post-translational modification enzyme, peptidyl arginine deiminase 4 (PAD4) could mediate the ...
Yanming Wang, Yuji Wang
exaly   +6 more sources

PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A

Neoplasia, 2022
Peptidylarginine deiminase 4 (PAD4), a Ca2+-dependent enzyme, catalyzes the conversion of arginine to citrulline and has been strongly associated with many malignant tumors.
Xinmin Fan
exaly   +3 more sources

Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting [PDF]

Frontiers in Pharmacology
Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes protein citrullination, a post-translational modification that can alter protein charge, conformation, and function. Among the mammalian peptidylarginine deiminase isoforms,
Ping Zou, Xiao-dan Su, Wei Tian, Xiang-yang Xie, Ke Yang   +4 more
doaj   +2 more sources

Breast Cancer-Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4-Dependent Extracellular Trap Formation. [PDF]

Mol Carcinog
ABSTRACT Neutrophil extracellular traps (NETs) play crucial roles in cancer progression, but their regulatory mechanisms in breast cancer remain poorly understood. We developed a NETs‐related prognostic risk model using TCGA breast cancer data and identified key biomarkers through bioinformatics analysis.
Huang Z, Wu Z, Zhu G, Qiu F, Li L, Xie Y, Wei C, Pan Y, Zou Q, Tang Y.   +9 more
europepmc   +2 more sources

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease. [PDF]

MedComm (2020)
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Zhang J, Wei F, Qu M, Shao Y, Xu T, Stojkov D, Simon HU, Huang B, Miao C, Zhang H.   +9 more
europepmc   +2 more sources

Compound phellodendron decoction promotes post-fistulotomy wound healing by downregulating neutrophil extracellular traps formation: evidence from a randomized trial and mechanistic studies [PDF]

Frontiers in Pharmacology
BackgroundPersistent inflammation and dysregulated neutrophil extracellular traps (NETs) are key factors impairing postoperative wound healing. While the traditional formula Compound Phellodendron Decoction (CPD) is clinically effective in sitz-bath ...
Ju Wang, Heng Deng, Shuo Chen, Hui Liu
doaj   +2 more sources

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture-Induced Sepsis and the Ameliorating Effects of Adipose-Derived Stem Cell Exosomes. [PDF]

Kaohsiung J Med Sci
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Wu SC, Lu TH, Wu YC, Lin CW, Tsai CW, Hsieh CH.   +5 more
europepmc   +2 more sources

Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition [PDF]

Biomolecules
Peptidyl arginine deiminase 4 (PAD4) is a Ca2+-dependent enzyme that catalyzes histone citrullination and plays a central role in chromatin decondensation during neutrophil extracellular trap (NET) formation.
Dong Oh Moon
doaj   +2 more sources

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility

Cell Reports, 2018
Summary: Recent proteome analyses have provided a comprehensive overview of various posttranslational modifications (PTMs); however, PTMs involving protein citrullination remain unclear. We performed a proteomic analysis of citrullinated proteins, and we
Koichi Matsuda, Aritoshi Iida, Kazuhiko Yamamoto   +2 more
exaly   +3 more sources

Structure–Activity Relationship of PAD4 Inhibitors and Their Role in Tumor Immunotherapy

Pharmaceutics
Protein arginine deiminase 4 (PAD4) plays an important role in cancer progression by participating in gene regulation, protein modification, and neutrophil extracellular trap (NET) formation.
Yanming Wang, Yuji Wang, Yijiang Jia
exaly   +3 more sources