Activation of PAD4 in NET formation [PDF]
Frontiers in Immunology, 2012 Peptidyl arginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates.
Daniel Slade +2 more
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PAD4 and Its Inhibitors in Cancer Progression and Prognosis
Pharmaceutics, 2022 The systemic spread of malignancies and the risk of cancer-associated thrombosis are major clinical challenges in cancer therapy worldwide. As an important post-translational modification enzyme, peptidyl arginine deiminase 4 (PAD4) could mediate the ...
Yanming Wang, Yuji Wang
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Mapping benefit, risk, and opportunity in PAD4 inhibition [PDF]
Frontiers in ImmunologyPeptidylarginine deiminase 4 (PAD4) is increasingly targeted to modulate inflammatory pathology, yet its inhibition produces biological effects that extend beyond the processes it was originally designed to suppress. While PAD4 targeting has largely been
Caio Santos Bonilha +2 more
doaj +5 more sources
Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting [PDF]
Frontiers in PharmacologyPeptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes protein citrullination, a post-translational modification that can alter protein charge, conformation, and function. Among the mammalian peptidylarginine deiminase isoforms,
Ping Zou +4 more
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Neoplasia, 2022 Peptidylarginine deiminase 4 (PAD4), a Ca2+-dependent enzyme, catalyzes the conversion of arginine to citrulline and has been strongly associated with many malignant tumors.
Xinmin Fan
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Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition [PDF]
BiomoleculesPeptidyl arginine deiminase 4 (PAD4) is a Ca2+-dependent enzyme that catalyzes histone citrullination and plays a central role in chromatin decondensation during neutrophil extracellular trap (NET) formation.
Dong Oh Moon
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Sex-specific effects of peptidyl arginine deiminase 4 deficiency in the cafeteria diet-induced obesity-associated metabolic complications [PDF]
Frontiers in EndocrinologyBackgroundObesity is a global health challenge linked to chronic non-communicable diseases. Low-grade inflammation and altered immune responses, including neutrophil extracellular trap (NET) formation, contribute to metabolic complications.
Andrej Feješ +9 more
doaj +2 more sources
Structure–Activity Relationship of PAD4 Inhibitors and Their Role in Tumor Immunotherapy
PharmaceuticsProtein arginine deiminase 4 (PAD4) plays an important role in cancer progression by participating in gene regulation, protein modification, and neutrophil extracellular trap (NET) formation.
Yanming Wang, Yuji Wang, Yijiang Jia
exaly +3 more sources
Expression of peptidylarginine deiminase 2 and 4 in malignant mesothelioma and its clinical significance [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression of peptidylarginine deiminase 2 and 4 (PAD2 and PAD4) in malignant mesothelioma (MM), their correlation with citrullinated proteins and clinical significance.
GAN Yihan, SHEN Wei, CHEN Yitong, YAN Kaili, HU Shuaiyue, JIANG Zhaoqiang, YING Shibo
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Autoimmunity, 2022 Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage.
Rachel W. Linnemann +5 more
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